Mechanisms of Resistance to Macrolide Antibiotics among Staphylococcus aureus

Methicillin resistant Staphylococcus aureus strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLSB) correlates with resistance to met...

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Autor principal:	Maria Miklasińska-Majdanik
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	macrolides resistance <i>Staphylococcus aureus</i> Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1b68abce93b1403b956b52b6138f474e
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spelling	oai:doaj.org-article:1b68abce93b1403b956b52b6138f474e2021-11-25T16:24:53ZMechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>10.3390/antibiotics101114062079-6382https://doaj.org/article/1b68abce93b1403b956b52b6138f474e2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1406https://doaj.org/toc/2079-6382Methicillin resistant <i>Staphylococcus aureus</i> strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLS<sub>B</sub>) correlates with resistance to methicillin. The rapid transmission of <i>erm</i> genes responsible for MLS<sub>B</sub> resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among <i>Staphylococcus aureus</i>.Maria Miklasińska-MajdanikMDPI AGarticlemacrolidesresistance<i>Staphylococcus aureus</i>Therapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1406, p 1406 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrolides resistance <i>Staphylococcus aureus</i> Therapeutics. Pharmacology RM1-950
spellingShingle	macrolides resistance <i>Staphylococcus aureus</i> Therapeutics. Pharmacology RM1-950 Maria Miklasińska-Majdanik Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
description	Methicillin resistant <i>Staphylococcus aureus</i> strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLS<sub>B</sub>) correlates with resistance to methicillin. The rapid transmission of <i>erm</i> genes responsible for MLS<sub>B</sub> resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among <i>Staphylococcus aureus</i>.
format	article
author	Maria Miklasińska-Majdanik
author_facet	Maria Miklasińska-Majdanik
author_sort	Maria Miklasińska-Majdanik
title	Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
title_short	Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
title_full	Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
title_fullStr	Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
title_full_unstemmed	Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
title_sort	mechanisms of resistance to macrolide antibiotics among <i>staphylococcus aureus</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1b68abce93b1403b956b52b6138f474e
work_keys_str_mv	AT mariamiklasinskamajdanik mechanismsofresistancetomacrolideantibioticsamongistaphylococcusaureusi
_version_	1718413184089456640

Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>

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