An atlas for human brain myelin content throughout the adult life span

Abstract Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with...

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Autores principales:	Adam V. Dvorak, Taylor Swift-LaPointe, Irene M. Vavasour, Lisa Eunyoung Lee, Shawna Abel, Bretta Russell-Schulz, Carina Graf, Anika Wurl, Hanwen Liu, Cornelia Laule, David K. B. Li, Anthony Traboulsee, Roger Tam, Lara A. Boyd, Alex L. MacKay, Shannon H. Kolind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b6a4ddc94404a0f90b8c1513016139e
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spelling	oai:doaj.org-article:1b6a4ddc94404a0f90b8c1513016139e2021-12-02T14:12:41ZAn atlas for human brain myelin content throughout the adult life span10.1038/s41598-020-79540-32045-2322https://doaj.org/article/1b6a4ddc94404a0f90b8c1513016139e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79540-3https://doaj.org/toc/2045-2322Abstract Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to create an optimized anatomical brain template and accompanying MWF and IET2 atlases. We then used the MWF atlas to characterize how myelin content relates to demographic factors. In most brain regions, myelin content followed a quadratic pattern of increase during the third decade of life, plateau at a maximum around the fifth decade, then decrease during later decades. The ranking of mean myelin content between brain regions remained consistent across age groups. These openly available normative atlases can facilitate evaluation of myelin imaging results on an individual basis and elucidate the distribution of myelin content between brain regions and in the context of aging.Adam V. DvorakTaylor Swift-LaPointeIrene M. VavasourLisa Eunyoung LeeShawna AbelBretta Russell-SchulzCarina GrafAnika WurlHanwen LiuCornelia LauleDavid K. B. LiAnthony TraboulseeRoger TamLara A. BoydAlex L. MacKayShannon H. KolindNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adam V. Dvorak Taylor Swift-LaPointe Irene M. Vavasour Lisa Eunyoung Lee Shawna Abel Bretta Russell-Schulz Carina Graf Anika Wurl Hanwen Liu Cornelia Laule David K. B. Li Anthony Traboulsee Roger Tam Lara A. Boyd Alex L. MacKay Shannon H. Kolind An atlas for human brain myelin content throughout the adult life span
description	Abstract Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to create an optimized anatomical brain template and accompanying MWF and IET2 atlases. We then used the MWF atlas to characterize how myelin content relates to demographic factors. In most brain regions, myelin content followed a quadratic pattern of increase during the third decade of life, plateau at a maximum around the fifth decade, then decrease during later decades. The ranking of mean myelin content between brain regions remained consistent across age groups. These openly available normative atlases can facilitate evaluation of myelin imaging results on an individual basis and elucidate the distribution of myelin content between brain regions and in the context of aging.
format	article
author	Adam V. Dvorak Taylor Swift-LaPointe Irene M. Vavasour Lisa Eunyoung Lee Shawna Abel Bretta Russell-Schulz Carina Graf Anika Wurl Hanwen Liu Cornelia Laule David K. B. Li Anthony Traboulsee Roger Tam Lara A. Boyd Alex L. MacKay Shannon H. Kolind
author_facet	Adam V. Dvorak Taylor Swift-LaPointe Irene M. Vavasour Lisa Eunyoung Lee Shawna Abel Bretta Russell-Schulz Carina Graf Anika Wurl Hanwen Liu Cornelia Laule David K. B. Li Anthony Traboulsee Roger Tam Lara A. Boyd Alex L. MacKay Shannon H. Kolind
author_sort	Adam V. Dvorak
title	An atlas for human brain myelin content throughout the adult life span
title_short	An atlas for human brain myelin content throughout the adult life span
title_full	An atlas for human brain myelin content throughout the adult life span
title_fullStr	An atlas for human brain myelin content throughout the adult life span
title_full_unstemmed	An atlas for human brain myelin content throughout the adult life span
title_sort	atlas for human brain myelin content throughout the adult life span
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b6a4ddc94404a0f90b8c1513016139e
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An atlas for human brain myelin content throughout the adult life span

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