Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents
Abstract Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, s-klotho has been proposed as a molecular biomarker of frailty and dep...
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Nature Portfolio
2021
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oai:doaj.org-article:1b6ded8089a24e1f81b1f197832e9a292021-12-02T13:41:43ZLow serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents10.1038/s41598-021-88455-62045-2322https://doaj.org/article/1b6ded8089a24e1f81b1f197832e9a292021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88455-6https://doaj.org/toc/2045-2322Abstract Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, s-klotho has been proposed as a molecular biomarker of frailty and dependence. This study is a secondary analysis of data from a clinical trial performed in a population of 103 older individuals living in 10 nursing homes in Gipuzkoa (Spain). We aimed to elucidate associations between s-klotho (as measured by enzyme-linked immunosorbent assay) and body composition, physical fitness, and cognition, as well as frailty and dependence (determined using validated tests and scales). In addition, we investigated the association of s-klotho concentration with falls in the six months following the initial assessment. Low s-klotho levels were associated with a lower score in the psychological component of the Tilburg Frailty Indicator, a worse score in the Coding Wechsler Adult Intelligence Scale, and a greater dependence in activities of daily living. Moreover, participants with lower s-klotho concentrations suffered more falls during the 6 months after the assessment. Future translational research should aim to validate klotho’s putative role as a biomarker that could identify the risk of aging-related adverse events in clinical practice.Begoña SanzHaritz ArrietaChloe Rezola-PardoAinhoa Fernández-AtutxaJon Garin-BalerdiNagore ArizagaAna Rodriguez-LarradJon IrazustaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Begoña Sanz Haritz Arrieta Chloe Rezola-Pardo Ainhoa Fernández-Atutxa Jon Garin-Balerdi Nagore Arizaga Ana Rodriguez-Larrad Jon Irazusta Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| description |
Abstract Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, s-klotho has been proposed as a molecular biomarker of frailty and dependence. This study is a secondary analysis of data from a clinical trial performed in a population of 103 older individuals living in 10 nursing homes in Gipuzkoa (Spain). We aimed to elucidate associations between s-klotho (as measured by enzyme-linked immunosorbent assay) and body composition, physical fitness, and cognition, as well as frailty and dependence (determined using validated tests and scales). In addition, we investigated the association of s-klotho concentration with falls in the six months following the initial assessment. Low s-klotho levels were associated with a lower score in the psychological component of the Tilburg Frailty Indicator, a worse score in the Coding Wechsler Adult Intelligence Scale, and a greater dependence in activities of daily living. Moreover, participants with lower s-klotho concentrations suffered more falls during the 6 months after the assessment. Future translational research should aim to validate klotho’s putative role as a biomarker that could identify the risk of aging-related adverse events in clinical practice. |
| format |
article |
| author |
Begoña Sanz Haritz Arrieta Chloe Rezola-Pardo Ainhoa Fernández-Atutxa Jon Garin-Balerdi Nagore Arizaga Ana Rodriguez-Larrad Jon Irazusta |
| author_facet |
Begoña Sanz Haritz Arrieta Chloe Rezola-Pardo Ainhoa Fernández-Atutxa Jon Garin-Balerdi Nagore Arizaga Ana Rodriguez-Larrad Jon Irazusta |
| author_sort |
Begoña Sanz |
| title |
Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| title_short |
Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| title_full |
Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| title_fullStr |
Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| title_full_unstemmed |
Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| title_sort |
low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1b6ded8089a24e1f81b1f197832e9a29 |
| work_keys_str_mv |
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