Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.

Recent studies have demonstrated that the topography of thalamocortical (TC) axon projections is initiated before they reach the cortex, in the ventral telencephalon (VTel). However, at this point, the molecular mechanisms patterning the topography of TC projections in the VTel remains poorly unders...

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Autores principales:	Ashton W Powell, Takayuki Sassa, Yongqin Wu, Marc Tessier-Lavigne, Franck Polleux
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1b72ad03c43d4fb7a6b1640f99b3441f
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spelling	oai:doaj.org-article:1b72ad03c43d4fb7a6b1640f99b3441f2021-11-25T05:33:21ZTopography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.1544-91731545-788510.1371/journal.pbio.0060116https://doaj.org/article/1b72ad03c43d4fb7a6b1640f99b3441f2008-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18479186/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Recent studies have demonstrated that the topography of thalamocortical (TC) axon projections is initiated before they reach the cortex, in the ventral telencephalon (VTel). However, at this point, the molecular mechanisms patterning the topography of TC projections in the VTel remains poorly understood. Here, we show that a long-range, high-rostral to low-caudal gradient of Netrin-1 in the VTel is required in vivo for the topographic sorting of TC axons to distinct cortical domains. We demonstrate that Netrin-1 is a chemoattractant for rostral thalamic axons but functions as a chemorepulsive cue for caudal thalamic axons. In accordance with this model, DCC is expressed in a high-rostromedial to low-caudolateral gradient in the dorsal thalamus (DTh), whereas three Unc5 receptors (Unc5A-C) show graded expression in the reverse orientation. Finally, we show that DCC is required for the attraction of rostromedial thalamic axons to the Netrin-1-rich, anterior part of the VTel, whereas DCC and Unc5A/C receptors are required for the repulsion of caudolateral TC axons from the same Netrin-1-rich region of the VTel. Our results demonstrate that a long-range gradient of Netrin-1 acts as a counteracting force from ephrin-A5 to control the topography of TC projections before they enter the cortex.Ashton W PowellTakayuki SassaYongqin WuMarc Tessier-LavigneFranck PolleuxPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 5, p e116 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ashton W Powell Takayuki Sassa Yongqin Wu Marc Tessier-Lavigne Franck Polleux Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.
description	Recent studies have demonstrated that the topography of thalamocortical (TC) axon projections is initiated before they reach the cortex, in the ventral telencephalon (VTel). However, at this point, the molecular mechanisms patterning the topography of TC projections in the VTel remains poorly understood. Here, we show that a long-range, high-rostral to low-caudal gradient of Netrin-1 in the VTel is required in vivo for the topographic sorting of TC axons to distinct cortical domains. We demonstrate that Netrin-1 is a chemoattractant for rostral thalamic axons but functions as a chemorepulsive cue for caudal thalamic axons. In accordance with this model, DCC is expressed in a high-rostromedial to low-caudolateral gradient in the dorsal thalamus (DTh), whereas three Unc5 receptors (Unc5A-C) show graded expression in the reverse orientation. Finally, we show that DCC is required for the attraction of rostromedial thalamic axons to the Netrin-1-rich, anterior part of the VTel, whereas DCC and Unc5A/C receptors are required for the repulsion of caudolateral TC axons from the same Netrin-1-rich region of the VTel. Our results demonstrate that a long-range gradient of Netrin-1 acts as a counteracting force from ephrin-A5 to control the topography of TC projections before they enter the cortex.
format	article
author	Ashton W Powell Takayuki Sassa Yongqin Wu Marc Tessier-Lavigne Franck Polleux
author_facet	Ashton W Powell Takayuki Sassa Yongqin Wu Marc Tessier-Lavigne Franck Polleux
author_sort	Ashton W Powell
title	Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.
title_short	Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.
title_full	Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.
title_fullStr	Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.
title_full_unstemmed	Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.
title_sort	topography of thalamic projections requires attractive and repulsive functions of netrin-1 in the ventral telencephalon.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/1b72ad03c43d4fb7a6b1640f99b3441f
work_keys_str_mv	AT ashtonwpowell topographyofthalamicprojectionsrequiresattractiveandrepulsivefunctionsofnetrin1intheventraltelencephalon AT takayukisassa topographyofthalamicprojectionsrequiresattractiveandrepulsivefunctionsofnetrin1intheventraltelencephalon AT yongqinwu topographyofthalamicprojectionsrequiresattractiveandrepulsivefunctionsofnetrin1intheventraltelencephalon AT marctessierlavigne topographyofthalamicprojectionsrequiresattractiveandrepulsivefunctionsofnetrin1intheventraltelencephalon AT franckpolleux topographyofthalamicprojectionsrequiresattractiveandrepulsivefunctionsofnetrin1intheventraltelencephalon
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Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon.

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