PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.

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Detalles Bibliográficos
Autores principales: Luke Russell, Jessica Swanner, Alena Cristina Jaime-Ramirez, Yufeng Wang, Alex Sprague, Yeshavanth Banasavadi-Siddegowda, Ji Young Yoo, Gina M. Sizemore, Raleigh Kladney, Jianying Zhang, Norman L. Lehman, Michael C Ostrowski, Bangxing Hong, Michael Caligiuri, Jianhua Yu, Balveen Kaur
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/1b78f9dcfbe44997ab5c1dfae77d5681
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Descripción
Sumario:Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.

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