PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.

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Autores principales:	Luke Russell, Jessica Swanner, Alena Cristina Jaime-Ramirez, Yufeng Wang, Alex Sprague, Yeshavanth Banasavadi-Siddegowda, Ji Young Yoo, Gina M. Sizemore, Raleigh Kladney, Jianying Zhang, Norman L. Lehman, Michael C Ostrowski, Bangxing Hong, Michael Caligiuri, Jianhua Yu, Balveen Kaur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b78f9dcfbe44997ab5c1dfae77d5681
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:1b78f9dcfbe44997ab5c1dfae77d56812021-12-02T17:31:45ZPTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance10.1038/s41467-018-07344-12041-1723https://doaj.org/article/1b78f9dcfbe44997ab5c1dfae77d56812018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07344-1https://doaj.org/toc/2041-1723Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.Luke RussellJessica SwannerAlena Cristina Jaime-RamirezYufeng WangAlex SpragueYeshavanth Banasavadi-SiddegowdaJi Young YooGina M. SizemoreRaleigh KladneyJianying ZhangNorman L. LehmanMichael C OstrowskiBangxing HongMichael CaligiuriJianhua YuBalveen KaurNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luke Russell Jessica Swanner Alena Cristina Jaime-Ramirez Yufeng Wang Alex Sprague Yeshavanth Banasavadi-Siddegowda Ji Young Yoo Gina M. Sizemore Raleigh Kladney Jianying Zhang Norman L. Lehman Michael C Ostrowski Bangxing Hong Michael Caligiuri Jianhua Yu Balveen Kaur PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
description	Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.
format	article
author	Luke Russell Jessica Swanner Alena Cristina Jaime-Ramirez Yufeng Wang Alex Sprague Yeshavanth Banasavadi-Siddegowda Ji Young Yoo Gina M. Sizemore Raleigh Kladney Jianying Zhang Norman L. Lehman Michael C Ostrowski Bangxing Hong Michael Caligiuri Jianhua Yu Balveen Kaur
author_facet	Luke Russell Jessica Swanner Alena Cristina Jaime-Ramirez Yufeng Wang Alex Sprague Yeshavanth Banasavadi-Siddegowda Ji Young Yoo Gina M. Sizemore Raleigh Kladney Jianying Zhang Norman L. Lehman Michael C Ostrowski Bangxing Hong Michael Caligiuri Jianhua Yu Balveen Kaur
author_sort	Luke Russell
title	PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
title_short	PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
title_full	PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
title_fullStr	PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
title_full_unstemmed	PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
title_sort	pten expression by an oncolytic herpesvirus directs t-cell mediated tumor clearance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b78f9dcfbe44997ab5c1dfae77d5681
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PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

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