Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

Abstract Brief thermo-nociceptive stimuli elicit low-frequency phase-locked local field potentials (LFPs) and high-frequency gamma-band oscillations (GBOs) in the human insula. Although neither of these responses constitute a direct correlate of pain perception, previous findings suggest that insula...

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Autores principales:	Giulia Liberati, Dounia Mulders, Maxime Algoet, Emanuel N. van den Broeke, Susana Ferrao Santos, José Géraldo Ribeiro Vaz, Christian Raftopoulos, André Mouraux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b794b3541e64070bf99e262da5507e9
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spelling	oai:doaj.org-article:1b794b3541e64070bf99e262da5507e92021-12-02T11:57:58ZInsular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG10.1038/s41598-020-79371-22045-2322https://doaj.org/article/1b794b3541e64070bf99e262da5507e92020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79371-2https://doaj.org/toc/2045-2322Abstract Brief thermo-nociceptive stimuli elicit low-frequency phase-locked local field potentials (LFPs) and high-frequency gamma-band oscillations (GBOs) in the human insula. Although neither of these responses constitute a direct correlate of pain perception, previous findings suggest that insular GBOs may be strongly related to the activation of the spinothalamic system and/or to the processing of thermal information. To disentangle these different features of the stimulation, we compared the insular responses to brief painful thermonociceptive stimuli, non-painful cool stimuli, mechano-nociceptive stimuli, and innocuous vibrotactile stimuli, recorded using intracerebral electroencephalograpic activity in 7 epileptic patients (9 depth electrodes, 58 insular contacts). All four types of stimuli elicited consistent low-frequency phase-locked LFPs throughout the insula, possibly reflecting supramodal activity. The latencies of thermo-nociceptive and cool low-frequency phase-locked LFPs were shorter in the posterior insula compared to the anterior insula, suggesting a similar processing of thermal input initiating in the posterior insula, regardless of whether the input produces pain and regardless of thermal modality. In contrast, only thermo-nociceptive stimuli elicited an enhancement of insular GBOs, suggesting that these activities are not simply related to the activation of the spinothalamic system or to the conveyance of thermal information.Giulia LiberatiDounia MuldersMaxime AlgoetEmanuel N. van den BroekeSusana Ferrao SantosJosé Géraldo Ribeiro VazChristian RaftopoulosAndré MourauxNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giulia Liberati Dounia Mulders Maxime Algoet Emanuel N. van den Broeke Susana Ferrao Santos José Géraldo Ribeiro Vaz Christian Raftopoulos André Mouraux Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
description	Abstract Brief thermo-nociceptive stimuli elicit low-frequency phase-locked local field potentials (LFPs) and high-frequency gamma-band oscillations (GBOs) in the human insula. Although neither of these responses constitute a direct correlate of pain perception, previous findings suggest that insular GBOs may be strongly related to the activation of the spinothalamic system and/or to the processing of thermal information. To disentangle these different features of the stimulation, we compared the insular responses to brief painful thermonociceptive stimuli, non-painful cool stimuli, mechano-nociceptive stimuli, and innocuous vibrotactile stimuli, recorded using intracerebral electroencephalograpic activity in 7 epileptic patients (9 depth electrodes, 58 insular contacts). All four types of stimuli elicited consistent low-frequency phase-locked LFPs throughout the insula, possibly reflecting supramodal activity. The latencies of thermo-nociceptive and cool low-frequency phase-locked LFPs were shorter in the posterior insula compared to the anterior insula, suggesting a similar processing of thermal input initiating in the posterior insula, regardless of whether the input produces pain and regardless of thermal modality. In contrast, only thermo-nociceptive stimuli elicited an enhancement of insular GBOs, suggesting that these activities are not simply related to the activation of the spinothalamic system or to the conveyance of thermal information.
format	article
author	Giulia Liberati Dounia Mulders Maxime Algoet Emanuel N. van den Broeke Susana Ferrao Santos José Géraldo Ribeiro Vaz Christian Raftopoulos André Mouraux
author_facet	Giulia Liberati Dounia Mulders Maxime Algoet Emanuel N. van den Broeke Susana Ferrao Santos José Géraldo Ribeiro Vaz Christian Raftopoulos André Mouraux
author_sort	Giulia Liberati
title	Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
title_short	Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
title_full	Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
title_fullStr	Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
title_full_unstemmed	Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG
title_sort	insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral eeg
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b794b3541e64070bf99e262da5507e9
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Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG

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