Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial

Jianmiao Wang,1 Yuping Zhang,1 Yuanyuan Chen,2 Mei Li,1 Hongyan Yang,2 Jinhua Chen,2 Qiaomin Tang,2 Jingfen Jin1,3 1Nursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Neurology Department,...

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Autores principales:	Wang J, Zhang Y, Chen Y, Li M, Yang H, Chen J, Tang Q, Jin J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	rehabilitation nursing acute ischemic stroke motor function. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1b79b04f22804dd4ae421c29ad6f6074
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spelling	oai:doaj.org-article:1b79b04f22804dd4ae421c29ad6f60742021-12-02T17:07:17ZEffectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial1178-1998https://doaj.org/article/1b79b04f22804dd4ae421c29ad6f60742021-06-01T00:00:00Zhttps://www.dovepress.com/effectiveness-of-rehabilitation-nursing-versus-usual-therapist-led-tre-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Jianmiao Wang,1 Yuping Zhang,1 Yuanyuan Chen,2 Mei Li,1 Hongyan Yang,2 Jinhua Chen,2 Qiaomin Tang,2 Jingfen Jin1,3 1Nursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Neurology Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 3Changxing Branch Hospital, The Second Affiliated Hospital of Zhejiang University School of Medicine, Huzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jingfen JinThe Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaFax +86-0571-87783778Email zrjzkhl@zju.edu.cnPurpose: To determine the effectiveness of rehabilitation nursing program interventions in patients with acute ischemic stroke.Patients and Methods: An assessment-blinded randomized controlled trial was conducted at a tertiary referral hospital in China. Eligible patients were stratified according to their weighted corticospinal tract lesion load and then randomly assigned to an experimental group (n = 121) or a control group (n = 103). The experimental group received rehabilitation nursing from well-trained, qualified nurses (30 minutes per session, two sessions per day for seven consecutive days). The control group received therapist-led rehabilitation with the same timing and frequency. Comparative analysis of the primary outcomes was performed to determine non-inferiority with a predetermined non-inferiority margin. The primary outcomes were the Motor Assessment Scale, Fugl-Meyer Assessment, and the Action Research Arm Test assessed at baseline and after seven days of treatment. The secondary outcomes were the modified Barthel Index, the National Institutes of Health Stroke Scale, and the modified Rankin Scale, evaluated before and after the intervention and at 4 and 12 weeks of follow-up.Results: Two hundred participants completed the trial. In both groups, all outcomes improved significantly after seven days and at follow-ups. The rehabilitation nursing program was non-inferior to therapist-led treatment with lower 95% confidence limits beyond the margins for primary outcomes (P < 0.001).Conclusion: Both treatments had comparable effects; however, no definite conclusion could be drawn. Adequately powered studies are required.Keywords: rehabilitation, nursing, acute ischemic stroke, motor functionWang JZhang YChen YLi MYang HChen JTang QJin JDove Medical Pressarticlerehabilitationnursingacute ischemic strokemotor function.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1173-1184 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rehabilitation nursing acute ischemic stroke motor function. Geriatrics RC952-954.6
spellingShingle	rehabilitation nursing acute ischemic stroke motor function. Geriatrics RC952-954.6 Wang J Zhang Y Chen Y Li M Yang H Chen J Tang Q Jin J Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial
description	Jianmiao Wang,1 Yuping Zhang,1 Yuanyuan Chen,2 Mei Li,1 Hongyan Yang,2 Jinhua Chen,2 Qiaomin Tang,2 Jingfen Jin1,3 1Nursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Neurology Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 3Changxing Branch Hospital, The Second Affiliated Hospital of Zhejiang University School of Medicine, Huzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jingfen JinThe Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaFax +86-0571-87783778Email zrjzkhl@zju.edu.cnPurpose: To determine the effectiveness of rehabilitation nursing program interventions in patients with acute ischemic stroke.Patients and Methods: An assessment-blinded randomized controlled trial was conducted at a tertiary referral hospital in China. Eligible patients were stratified according to their weighted corticospinal tract lesion load and then randomly assigned to an experimental group (n = 121) or a control group (n = 103). The experimental group received rehabilitation nursing from well-trained, qualified nurses (30 minutes per session, two sessions per day for seven consecutive days). The control group received therapist-led rehabilitation with the same timing and frequency. Comparative analysis of the primary outcomes was performed to determine non-inferiority with a predetermined non-inferiority margin. The primary outcomes were the Motor Assessment Scale, Fugl-Meyer Assessment, and the Action Research Arm Test assessed at baseline and after seven days of treatment. The secondary outcomes were the modified Barthel Index, the National Institutes of Health Stroke Scale, and the modified Rankin Scale, evaluated before and after the intervention and at 4 and 12 weeks of follow-up.Results: Two hundred participants completed the trial. In both groups, all outcomes improved significantly after seven days and at follow-ups. The rehabilitation nursing program was non-inferior to therapist-led treatment with lower 95% confidence limits beyond the margins for primary outcomes (P < 0.001).Conclusion: Both treatments had comparable effects; however, no definite conclusion could be drawn. Adequately powered studies are required.Keywords: rehabilitation, nursing, acute ischemic stroke, motor function
format	article
author	Wang J Zhang Y Chen Y Li M Yang H Chen J Tang Q Jin J
author_facet	Wang J Zhang Y Chen Y Li M Yang H Chen J Tang Q Jin J
author_sort	Wang J
title	Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial
title_short	Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial
title_full	Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial
title_fullStr	Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial
title_full_unstemmed	Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial
title_sort	effectiveness of rehabilitation nursing versus usual therapist-led treatment in patients with acute ischemic stroke: a randomized non-inferiority trial
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1b79b04f22804dd4ae421c29ad6f6074
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Effectiveness of Rehabilitation Nursing versus Usual Therapist-Led Treatment in Patients with Acute Ischemic Stroke: A Randomized Non-Inferiority Trial

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