Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines

Three piperidone curcumin analogues (N-methyl-(3E,5E)-3,5-bis-(2-chlorobenzylidene)-4-piperidone (1), N-methyl-(3E,5E)-3,5-bis-(3-bromobenzylidene)-4-piperidone (2) and N-methyl-(3E,5E)-3,5-bis-(4-chlorobenzylidene)-4-piperidone (3)) were synthesized from N-methyl-4-piperidone with halogenbenzaldehy...

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Autores principales:	Yum Eryanti, Rudi Hendra, Tati Herlina, Adel Zamri, Unang Supratman
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2018
Materias:	curcumin condensation Claisen-Schmidt cytotoxicity T47D Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1b7a456f2b1b4671b8dd3a62fedbade5
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spelling	oai:doaj.org-article:1b7a456f2b1b4671b8dd3a62fedbade52021-12-02T11:45:55ZSynthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines1411-94202460-157810.22146/ijc.24174https://doaj.org/article/1b7a456f2b1b4671b8dd3a62fedbade52018-05-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/24174https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578Three piperidone curcumin analogues (N-methyl-(3E,5E)-3,5-bis-(2-chlorobenzylidene)-4-piperidone (1), N-methyl-(3E,5E)-3,5-bis-(3-bromobenzylidene)-4-piperidone (2) and N-methyl-(3E,5E)-3,5-bis-(4-chlorobenzylidene)-4-piperidone (3)) were synthesized from N-methyl-4-piperidone with halogenbenzaldehyde, 2-chlorobenzaldehyde, 3-bromobenzaldehyde and 4-chlorobenzaldehyde. The Claisen-Schmidt condensation reaction was used in alkali condition with combinatorial. All the compounds showed light yellow needle, light yellow powder, and yellow crystal form with percentage of yield 39, 66, and 40%, respectively. All the structure compounds were confirmed by using UV, IR, 13C-NMR, 1H-NMR and MS. Apart from that, the cytotoxicity results against breast cancer cell (T47D) showed strong to moderate activity with the IC50 value 8, 4, and 45 µg/mL, respectively.Yum EryantiRudi HendraTati HerlinaAdel ZamriUnang SupratmanDepartment of Chemistry, Universitas Gadjah MadaarticlecurcumincondensationClaisen-Schmidtcytotoxicity T47DChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 18, Iss 2, Pp 362-366 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin condensation Claisen-Schmidt cytotoxicity T47D Chemistry QD1-999
spellingShingle	curcumin condensation Claisen-Schmidt cytotoxicity T47D Chemistry QD1-999 Yum Eryanti Rudi Hendra Tati Herlina Adel Zamri Unang Supratman Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
description	Three piperidone curcumin analogues (N-methyl-(3E,5E)-3,5-bis-(2-chlorobenzylidene)-4-piperidone (1), N-methyl-(3E,5E)-3,5-bis-(3-bromobenzylidene)-4-piperidone (2) and N-methyl-(3E,5E)-3,5-bis-(4-chlorobenzylidene)-4-piperidone (3)) were synthesized from N-methyl-4-piperidone with halogenbenzaldehyde, 2-chlorobenzaldehyde, 3-bromobenzaldehyde and 4-chlorobenzaldehyde. The Claisen-Schmidt condensation reaction was used in alkali condition with combinatorial. All the compounds showed light yellow needle, light yellow powder, and yellow crystal form with percentage of yield 39, 66, and 40%, respectively. All the structure compounds were confirmed by using UV, IR, 13C-NMR, 1H-NMR and MS. Apart from that, the cytotoxicity results against breast cancer cell (T47D) showed strong to moderate activity with the IC50 value 8, 4, and 45 µg/mL, respectively.
format	article
author	Yum Eryanti Rudi Hendra Tati Herlina Adel Zamri Unang Supratman
author_facet	Yum Eryanti Rudi Hendra Tati Herlina Adel Zamri Unang Supratman
author_sort	Yum Eryanti
title	Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
title_short	Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
title_full	Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
title_fullStr	Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
title_full_unstemmed	Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
title_sort	synthesis of n-methyl-4-piperidone curcumin analogues and their cytotoxicity activity against t47d cell lines
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2018
url	https://doaj.org/article/1b7a456f2b1b4671b8dd3a62fedbade5
work_keys_str_mv	AT yumeryanti synthesisofnmethyl4piperidonecurcuminanaloguesandtheircytotoxicityactivityagainstt47dcelllines AT rudihendra synthesisofnmethyl4piperidonecurcuminanaloguesandtheircytotoxicityactivityagainstt47dcelllines AT tatiherlina synthesisofnmethyl4piperidonecurcuminanaloguesandtheircytotoxicityactivityagainstt47dcelllines AT adelzamri synthesisofnmethyl4piperidonecurcuminanaloguesandtheircytotoxicityactivityagainstt47dcelllines AT unangsupratman synthesisofnmethyl4piperidonecurcuminanaloguesandtheircytotoxicityactivityagainstt47dcelllines
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Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines

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