Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift

Gaining insight into cell identities from single cell RNA-seq data remains a challenge. Here, the authors introduce an approach to identify transcription factors (TFs) that synergistically determine cellular identities, and demonstrate its ability to identify TFs that can induce cellular conversion.

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Autores principales:	Satoshi Okawa, Carmen Saltó, Srikanth Ravichandran, Shanzheng Yang, Enrique M. Toledo, Ernest Arenas, Antonio del Sol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b7c6baab5e84bcfa07a16f64922ceec
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spelling	oai:doaj.org-article:1b7c6baab5e84bcfa07a16f64922ceec2021-12-02T16:56:57ZTranscriptional synergy as an emergent property defining cell subpopulation identity enables population shift10.1038/s41467-018-05016-82041-1723https://doaj.org/article/1b7c6baab5e84bcfa07a16f64922ceec2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05016-8https://doaj.org/toc/2041-1723Gaining insight into cell identities from single cell RNA-seq data remains a challenge. Here, the authors introduce an approach to identify transcription factors (TFs) that synergistically determine cellular identities, and demonstrate its ability to identify TFs that can induce cellular conversion.Satoshi OkawaCarmen SaltóSrikanth RavichandranShanzheng YangEnrique M. ToledoErnest ArenasAntonio del SolNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoshi Okawa Carmen Saltó Srikanth Ravichandran Shanzheng Yang Enrique M. Toledo Ernest Arenas Antonio del Sol Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
description	Gaining insight into cell identities from single cell RNA-seq data remains a challenge. Here, the authors introduce an approach to identify transcription factors (TFs) that synergistically determine cellular identities, and demonstrate its ability to identify TFs that can induce cellular conversion.
format	article
author	Satoshi Okawa Carmen Saltó Srikanth Ravichandran Shanzheng Yang Enrique M. Toledo Ernest Arenas Antonio del Sol
author_facet	Satoshi Okawa Carmen Saltó Srikanth Ravichandran Shanzheng Yang Enrique M. Toledo Ernest Arenas Antonio del Sol
author_sort	Satoshi Okawa
title	Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
title_short	Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
title_full	Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
title_fullStr	Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
title_full_unstemmed	Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
title_sort	transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b7c6baab5e84bcfa07a16f64922ceec
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Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift

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