Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift

Gaining insight into cell identities from single cell RNA-seq data remains a challenge. Here, the authors introduce an approach to identify transcription factors (TFs) that synergistically determine cellular identities, and demonstrate its ability to identify TFs that can induce cellular conversion.

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Autores principales: Satoshi Okawa, Carmen Saltó, Srikanth Ravichandran, Shanzheng Yang, Enrique M. Toledo, Ernest Arenas, Antonio del Sol
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1b7c6baab5e84bcfa07a16f64922ceec
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