Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo

Delivery of therapeutic proteins to patients may be costly to administer, and often requires repeated injections. Here, the authors use antigen-specific T cells expressing erythropoietin, and show that following transfer in mice, cell expansion and erythropoietin production can be boosted by vaccina...

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Autores principales:	Richard T. O’Neil, Sunandan Saha, Ruth Ann Veach, Richard C. Welch, Lauren E. Woodard, Cliona M. Rooney, Matthew H. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b801fcca3ce4879a9a7f67891d2af75
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spelling	oai:doaj.org-article:1b801fcca3ce4879a9a7f67891d2af752021-12-02T15:34:40ZTransposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo10.1038/s41467-018-03787-82041-1723https://doaj.org/article/1b801fcca3ce4879a9a7f67891d2af752018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03787-8https://doaj.org/toc/2041-1723Delivery of therapeutic proteins to patients may be costly to administer, and often requires repeated injections. Here, the authors use antigen-specific T cells expressing erythropoietin, and show that following transfer in mice, cell expansion and erythropoietin production can be boosted by vaccination, raising the haematocrit.Richard T. O’NeilSunandan SahaRuth Ann VeachRichard C. WelchLauren E. WoodardCliona M. RooneyMatthew H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Richard T. O’Neil Sunandan Saha Ruth Ann Veach Richard C. Welch Lauren E. Woodard Cliona M. Rooney Matthew H. Wilson Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
description	Delivery of therapeutic proteins to patients may be costly to administer, and often requires repeated injections. Here, the authors use antigen-specific T cells expressing erythropoietin, and show that following transfer in mice, cell expansion and erythropoietin production can be boosted by vaccination, raising the haematocrit.
format	article
author	Richard T. O’Neil Sunandan Saha Ruth Ann Veach Richard C. Welch Lauren E. Woodard Cliona M. Rooney Matthew H. Wilson
author_facet	Richard T. O’Neil Sunandan Saha Ruth Ann Veach Richard C. Welch Lauren E. Woodard Cliona M. Rooney Matthew H. Wilson
author_sort	Richard T. O’Neil
title	Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
title_short	Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
title_full	Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
title_fullStr	Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
title_full_unstemmed	Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
title_sort	transposon-modified antigen-specific t lymphocytes for sustained therapeutic protein delivery in vivo
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b801fcca3ce4879a9a7f67891d2af75
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Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo

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