Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

Abstract Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted d...

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Autores principales:	Wesam Mulla, Sharon Etzion, Sigal Elyagon, Roni Gillis, Michael Murninkas, Yuval Konstantino, Ingra Mannhardt, Thomas Eschenhagen, Noah Liel-Cohen, Yoram Etzion
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b80f5c0b91e45ae981ef13347b870f7
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spelling	oai:doaj.org-article:1b80f5c0b91e45ae981ef13347b870f72021-12-02T12:31:54ZProminent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats10.1038/s41598-017-06197-w2045-2322https://doaj.org/article/1b80f5c0b91e45ae981ef13347b870f72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06197-whttps://doaj.org/toc/2045-2322Abstract Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for double-site epicardial pacing in rats and echocardiographically demonstrated favorable effects of LV and biventricular (LV-based) pacing modes typically observed in humans. Here, this new animal model was further characterized. Electrodes were implanted either on the right atria (RA) and right ventricle (RV) or on the RV and LV. Following recovery, rats were either used for invasive hemodynamic measurements (pressure-volume analysis) or exposed to sustained RV vs. biventricular tachypacing for 3 days. RV pacing compromised, while LV-based pacing modes markedly enhanced cardiac performance. Changes in LV performance were associated with prominent compensatory changes in arterial resistance. Sustained RV tachypacing increased the electrocardiogram QTc interval by 7.9 ± 3.1 ms (n = 6, p < 0.05), dispersed refractoriness between the right and left pacing sites and induced important molecular changes mainly in the early-activated septal tissue. These effects were not observed during biventricular tachypacing (n = 6). Our results demonstrate that the rat is an attractive new model to study the biological consequences of LV dyssynchrony and resynchronization.Wesam MullaSharon EtzionSigal ElyagonRoni GillisMichael MurninkasYuval KonstantinoIngra MannhardtThomas EschenhagenNoah Liel-CohenYoram EtzionNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wesam Mulla Sharon Etzion Sigal Elyagon Roni Gillis Michael Murninkas Yuval Konstantino Ingra Mannhardt Thomas Eschenhagen Noah Liel-Cohen Yoram Etzion Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
description	Abstract Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for double-site epicardial pacing in rats and echocardiographically demonstrated favorable effects of LV and biventricular (LV-based) pacing modes typically observed in humans. Here, this new animal model was further characterized. Electrodes were implanted either on the right atria (RA) and right ventricle (RV) or on the RV and LV. Following recovery, rats were either used for invasive hemodynamic measurements (pressure-volume analysis) or exposed to sustained RV vs. biventricular tachypacing for 3 days. RV pacing compromised, while LV-based pacing modes markedly enhanced cardiac performance. Changes in LV performance were associated with prominent compensatory changes in arterial resistance. Sustained RV tachypacing increased the electrocardiogram QTc interval by 7.9 ± 3.1 ms (n = 6, p < 0.05), dispersed refractoriness between the right and left pacing sites and induced important molecular changes mainly in the early-activated septal tissue. These effects were not observed during biventricular tachypacing (n = 6). Our results demonstrate that the rat is an attractive new model to study the biological consequences of LV dyssynchrony and resynchronization.
format	article
author	Wesam Mulla Sharon Etzion Sigal Elyagon Roni Gillis Michael Murninkas Yuval Konstantino Ingra Mannhardt Thomas Eschenhagen Noah Liel-Cohen Yoram Etzion
author_facet	Wesam Mulla Sharon Etzion Sigal Elyagon Roni Gillis Michael Murninkas Yuval Konstantino Ingra Mannhardt Thomas Eschenhagen Noah Liel-Cohen Yoram Etzion
author_sort	Wesam Mulla
title	Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
title_short	Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
title_full	Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
title_fullStr	Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
title_full_unstemmed	Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
title_sort	prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1b80f5c0b91e45ae981ef13347b870f7
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Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

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