New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers

Abstract Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers. However, its clinical application is often limited by severe toxic side effects and drug resistance. Based on the discovered dissociative electr...

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Autores principales:	Qinrong Zhang, Qing-Bin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b840da4cafb4edda19ef2f7542f0ab8
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spelling	oai:doaj.org-article:1b840da4cafb4edda19ef2f7542f0ab82021-12-02T14:01:32ZNew combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers10.1038/s41598-020-80876-z2045-2322https://doaj.org/article/1b840da4cafb4edda19ef2f7542f0ab82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80876-zhttps://doaj.org/toc/2045-2322Abstract Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers. However, its clinical application is often limited by severe toxic side effects and drug resistance. Based on the discovered dissociative electron transfer mechanism of cisplatin, a novel combination of cisplatin with [9-(2-carboxyphenyl)-6-diethylamino-3-xanthenylidene]-diethylammonium chloride (basic violet 10, BV10) is proposed to potentiate the chemotherapeutic effect of cisplatin. Here, we show that this combination enhances the anti-cancer effect of cisplatin in both in vitro cell lines and in vivo xenograft mouse models of cisplatin-sensitive and -resistant lung, ovarian and cervical cancers while introducing minimal additional toxic side effects. Furthermore, femtosecond time-resolved laser spectroscopic measurements demonstrate that cisplatin reacts with BV10 via an electron transfer mechanism. These results indicate that the combination of cisplatin with BV10 is promising for improving the chemotherapy of cancers with various extents of cisplatin resistance.Qinrong ZhangQing-Bin LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qinrong Zhang Qing-Bin Lu New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
description	Abstract Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers. However, its clinical application is often limited by severe toxic side effects and drug resistance. Based on the discovered dissociative electron transfer mechanism of cisplatin, a novel combination of cisplatin with [9-(2-carboxyphenyl)-6-diethylamino-3-xanthenylidene]-diethylammonium chloride (basic violet 10, BV10) is proposed to potentiate the chemotherapeutic effect of cisplatin. Here, we show that this combination enhances the anti-cancer effect of cisplatin in both in vitro cell lines and in vivo xenograft mouse models of cisplatin-sensitive and -resistant lung, ovarian and cervical cancers while introducing minimal additional toxic side effects. Furthermore, femtosecond time-resolved laser spectroscopic measurements demonstrate that cisplatin reacts with BV10 via an electron transfer mechanism. These results indicate that the combination of cisplatin with BV10 is promising for improving the chemotherapy of cancers with various extents of cisplatin resistance.
format	article
author	Qinrong Zhang Qing-Bin Lu
author_facet	Qinrong Zhang Qing-Bin Lu
author_sort	Qinrong Zhang
title	New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
title_short	New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
title_full	New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
title_fullStr	New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
title_full_unstemmed	New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
title_sort	new combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b840da4cafb4edda19ef2f7542f0ab8
work_keys_str_mv	AT qinrongzhang newcombinationchemotherapyofcisplatinwithanelectrondonatingcompoundfortreatmentofmultiplecancers AT qingbinlu newcombinationchemotherapyofcisplatinwithanelectrondonatingcompoundfortreatmentofmultiplecancers
_version_	1718392125346807808

New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers

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