Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys

Abstract The China-origin H7N9 low pathogenicity avian influenza virus (LPAIV) emerged as a zoonotic threat in 2013 where it continues to circulate in live poultry markets. Absence of overt clinical signs in poultry is a typical LPAIV infection outcome, and has contributed to its insidious maintenan...

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Autores principales:	Marek J. Slomka, Amanda H. Seekings, Sahar Mahmood, Saumya Thomas, Anita Puranik, Samantha Watson, Alexander M. P. Byrne, Daniel Hicks, Alejandro Nunez, Ian H. Brown, Sharon M. Brookes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b8b09714fa947459ac0bf30294e3ba9
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spelling	oai:doaj.org-article:1b8b09714fa947459ac0bf30294e3ba92021-12-02T11:40:53ZUnexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys10.1038/s41598-018-25062-y2045-2322https://doaj.org/article/1b8b09714fa947459ac0bf30294e3ba92018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25062-yhttps://doaj.org/toc/2045-2322Abstract The China-origin H7N9 low pathogenicity avian influenza virus (LPAIV) emerged as a zoonotic threat in 2013 where it continues to circulate in live poultry markets. Absence of overt clinical signs in poultry is a typical LPAIV infection outcome, and has contributed to its insidious maintenance in China. This study is the first description of H7N9 LPAIV (A/Anhui/1/13) infection in turkeys, with efficient transmission to two additional rounds of introduced contact turkeys which all became infected during cohousing. Surprisingly, mortality was observed in six of eight (75%) second-round contact turkeys which is unusual for LPAIV infection, with unexpected systemic dissemination to many organs beyond the respiratory and enteric tracts, but interestingly no accompanying mutation to highly pathogenic AIV. The intravenous pathogenicity index score for a turkey-derived isolate (0.39) affirmed the LPAIV phenotype. However, the amino acid change L235Q in the haemagglutinin gene occurred in directly-infected turkeys and transmitted to the contacts, including those that died and the two which resolved infection to survive to the end of the study. This polymorphism was indicative of a reversion from mammalian to avian adaptation for the H7N9 virus. This study underlined a new risk to poultry in the event of H7N9 spread beyond China.Marek J. SlomkaAmanda H. SeekingsSahar MahmoodSaumya ThomasAnita PuranikSamantha WatsonAlexander M. P. ByrneDaniel HicksAlejandro NunezIan H. BrownSharon M. BrookesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marek J. Slomka Amanda H. Seekings Sahar Mahmood Saumya Thomas Anita Puranik Samantha Watson Alexander M. P. Byrne Daniel Hicks Alejandro Nunez Ian H. Brown Sharon M. Brookes Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys
description	Abstract The China-origin H7N9 low pathogenicity avian influenza virus (LPAIV) emerged as a zoonotic threat in 2013 where it continues to circulate in live poultry markets. Absence of overt clinical signs in poultry is a typical LPAIV infection outcome, and has contributed to its insidious maintenance in China. This study is the first description of H7N9 LPAIV (A/Anhui/1/13) infection in turkeys, with efficient transmission to two additional rounds of introduced contact turkeys which all became infected during cohousing. Surprisingly, mortality was observed in six of eight (75%) second-round contact turkeys which is unusual for LPAIV infection, with unexpected systemic dissemination to many organs beyond the respiratory and enteric tracts, but interestingly no accompanying mutation to highly pathogenic AIV. The intravenous pathogenicity index score for a turkey-derived isolate (0.39) affirmed the LPAIV phenotype. However, the amino acid change L235Q in the haemagglutinin gene occurred in directly-infected turkeys and transmitted to the contacts, including those that died and the two which resolved infection to survive to the end of the study. This polymorphism was indicative of a reversion from mammalian to avian adaptation for the H7N9 virus. This study underlined a new risk to poultry in the event of H7N9 spread beyond China.
format	article
author	Marek J. Slomka Amanda H. Seekings Sahar Mahmood Saumya Thomas Anita Puranik Samantha Watson Alexander M. P. Byrne Daniel Hicks Alejandro Nunez Ian H. Brown Sharon M. Brookes
author_facet	Marek J. Slomka Amanda H. Seekings Sahar Mahmood Saumya Thomas Anita Puranik Samantha Watson Alexander M. P. Byrne Daniel Hicks Alejandro Nunez Ian H. Brown Sharon M. Brookes
author_sort	Marek J. Slomka
title	Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys
title_short	Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys
title_full	Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys
title_fullStr	Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys
title_full_unstemmed	Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys
title_sort	unexpected infection outcomes of china-origin h7n9 low pathogenicity avian influenza virus in turkeys
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b8b09714fa947459ac0bf30294e3ba9
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Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys

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