NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling

NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling

NOTCH4 is a member of the NOTCH family of receptors whose expression is intensively induced in macrophages after their activation by Toll-like receptors (TLR) and/or interferon-γ (IFN-γ). In this work, we show that this receptor acts as a negative regulator of macrophage activation by diminishing th...

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Bibliographic Details
Main Authors: Susana López-López, María José Romero de Ávila, Natalia Carolina Hernández de León, Francisco Ruiz-Marcos, Victoriano Baladrón, María Luisa Nueda, Jorge Laborda, José Javier García-Ramírez, Eva M. Monsalve, María José M. Díaz-Guerra
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
macrophage
inflammation
NOTCH4
IFN-γ
TLR
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/1b8d94105a284db482368c8e152f64b1
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https://doaj.org/article/1b8d94105a284db482368c8e152f64b1

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