Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease

Cinnamon procyanidin oligomers (CPOs) are water-soluble components extracted from cinnamon. This study aims to explore the neuroprotection of B-type CPO (CPO-B) against 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>)-mediated cytotoxicity and the molecular mechanisms underlying its protect...

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Autores principales:	Qi Xu, Ziyu Chen, Borong Zhu, Yiming Li, Manju B. Reddy, Huilin Liu, Guodong Dang, Qi Jia, Xiaojun Wu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Parkinson’s disease CPO-B MPP<sup>+</sup> Erk1/2 neuroprotection Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/1b914925553a455e842eb64b3033b9bc
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spelling	oai:doaj.org-article:1b914925553a455e842eb64b3033b9bc2021-11-11T18:26:23ZNeuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease10.3390/molecules262164221420-3049https://doaj.org/article/1b914925553a455e842eb64b3033b9bc2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6422https://doaj.org/toc/1420-3049Cinnamon procyanidin oligomers (CPOs) are water-soluble components extracted from cinnamon. This study aims to explore the neuroprotection of B-type CPO (CPO-B) against 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>)-mediated cytotoxicity and the molecular mechanisms underlying its protection. The results demonstrated that CPO-B showed protection by increasing cell viability, attenuating an intracellular level of reactive oxygen species, downregulating cleaved caspase-3 expression, and upregulating the Bcl-2/Bax ratio. Moreover, CPO-B completely blocked the dephosphorylation of extracellular, signal-regulated kinase 1 and 2 (Erk1/2) caused by MPP<sup>+</sup>. Treatment with an Erk1/2 inhibitor, SCH772984, significantly abolished the neuroprotection of CPO-B against MPP<sup>+</sup>. Taken together, we demonstrate that CPO-B from cinnamon bark provided protection against MPP<sup>+</sup> in cultured SH-SY5Y cells, and the potential mechanisms may be attributed to its ability to modulate the dysregulation between pro-apoptotic and anti-apoptotic proteins through the Erk1/2 signaling pathway. Our findings suggest that the addition of cinnamon to food or supplements might benefit patients with PD.Qi XuZiyu ChenBorong ZhuYiming LiManju B. ReddyHuilin LiuGuodong DangQi JiaXiaojun WuMDPI AGarticleParkinson’s diseaseCPO-BMPP<sup>+</sup>Erk1/2neuroprotectionOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6422, p 6422 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease CPO-B MPP<sup>+</sup> Erk1/2 neuroprotection Organic chemistry QD241-441
spellingShingle	Parkinson’s disease CPO-B MPP<sup>+</sup> Erk1/2 neuroprotection Organic chemistry QD241-441 Qi Xu Ziyu Chen Borong Zhu Yiming Li Manju B. Reddy Huilin Liu Guodong Dang Qi Jia Xiaojun Wu Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
description	Cinnamon procyanidin oligomers (CPOs) are water-soluble components extracted from cinnamon. This study aims to explore the neuroprotection of B-type CPO (CPO-B) against 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>)-mediated cytotoxicity and the molecular mechanisms underlying its protection. The results demonstrated that CPO-B showed protection by increasing cell viability, attenuating an intracellular level of reactive oxygen species, downregulating cleaved caspase-3 expression, and upregulating the Bcl-2/Bax ratio. Moreover, CPO-B completely blocked the dephosphorylation of extracellular, signal-regulated kinase 1 and 2 (Erk1/2) caused by MPP<sup>+</sup>. Treatment with an Erk1/2 inhibitor, SCH772984, significantly abolished the neuroprotection of CPO-B against MPP<sup>+</sup>. Taken together, we demonstrate that CPO-B from cinnamon bark provided protection against MPP<sup>+</sup> in cultured SH-SY5Y cells, and the potential mechanisms may be attributed to its ability to modulate the dysregulation between pro-apoptotic and anti-apoptotic proteins through the Erk1/2 signaling pathway. Our findings suggest that the addition of cinnamon to food or supplements might benefit patients with PD.
format	article
author	Qi Xu Ziyu Chen Borong Zhu Yiming Li Manju B. Reddy Huilin Liu Guodong Dang Qi Jia Xiaojun Wu
author_facet	Qi Xu Ziyu Chen Borong Zhu Yiming Li Manju B. Reddy Huilin Liu Guodong Dang Qi Jia Xiaojun Wu
author_sort	Qi Xu
title	Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
title_short	Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
title_full	Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
title_fullStr	Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
title_full_unstemmed	Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease
title_sort	neuroprotective effects of b-type cinnamon procyanidin oligomers on mpp<sup>+</sup>-induced apoptosis in a cell culture model of parkinson’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1b914925553a455e842eb64b3033b9bc
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Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP<sup>+</sup>-Induced Apoptosis in a Cell Culture Model of Parkinson’s Disease

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