Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration

Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt–Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection...

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Autores principales:	Dumitru Ciolac, Renata Racila, Carolina Duarte, Maria Vasilieva, Diana Manea, Nadejda Gorincioi, Alexandra Condrea, Igor Crivorucica, Eremei Zota, Daniela Efremova, Veaceslav Crivorucica, Mihail Ciocanu, Alexandru Movila, Stanislav A. Groppa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Creutzfeldt–Jakob disease SARS-CoV-2 accelerated neurodegeneration aging Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1b91cb7099fd4bcfafcbb1f6044ebac4
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spelling	oai:doaj.org-article:1b91cb7099fd4bcfafcbb1f6044ebac42021-11-25T16:51:30ZClinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration10.3390/biomedicines91117302227-9059https://doaj.org/article/1b91cb7099fd4bcfafcbb1f6044ebac42021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1730https://doaj.org/toc/2227-9059Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt–Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the progression of the disease, a dismal outcome ensued. This report further evidences the age-dependent neurological effects of SARS-CoV-2 infection and proposes a vulnerability to CJD and increased CJD progression following COVID-19.Dumitru CiolacRenata RacilaCarolina DuarteMaria VasilievaDiana ManeaNadejda GorincioiAlexandra CondreaIgor CrivorucicaEremei ZotaDaniela EfremovaVeaceslav CrivorucicaMihail CiocanuAlexandru MovilaStanislav A. GroppaMDPI AGarticleCreutzfeldt–Jakob diseaseSARS-CoV-2accelerated neurodegenerationagingBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1730, p 1730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Creutzfeldt–Jakob disease SARS-CoV-2 accelerated neurodegeneration aging Biology (General) QH301-705.5
spellingShingle	Creutzfeldt–Jakob disease SARS-CoV-2 accelerated neurodegeneration aging Biology (General) QH301-705.5 Dumitru Ciolac Renata Racila Carolina Duarte Maria Vasilieva Diana Manea Nadejda Gorincioi Alexandra Condrea Igor Crivorucica Eremei Zota Daniela Efremova Veaceslav Crivorucica Mihail Ciocanu Alexandru Movila Stanislav A. Groppa Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration
description	Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt–Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the progression of the disease, a dismal outcome ensued. This report further evidences the age-dependent neurological effects of SARS-CoV-2 infection and proposes a vulnerability to CJD and increased CJD progression following COVID-19.
format	article
author	Dumitru Ciolac Renata Racila Carolina Duarte Maria Vasilieva Diana Manea Nadejda Gorincioi Alexandra Condrea Igor Crivorucica Eremei Zota Daniela Efremova Veaceslav Crivorucica Mihail Ciocanu Alexandru Movila Stanislav A. Groppa
author_facet	Dumitru Ciolac Renata Racila Carolina Duarte Maria Vasilieva Diana Manea Nadejda Gorincioi Alexandra Condrea Igor Crivorucica Eremei Zota Daniela Efremova Veaceslav Crivorucica Mihail Ciocanu Alexandru Movila Stanislav A. Groppa
author_sort	Dumitru Ciolac
title	Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration
title_short	Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration
title_full	Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration
title_fullStr	Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration
title_full_unstemmed	Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration
title_sort	clinical and radiological deterioration in a case of creutzfeldt–jakob disease following sars-cov-2 infection: hints to accelerated age-dependent neurodegeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1b91cb7099fd4bcfafcbb1f6044ebac4
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Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration

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