Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in the activation of core Hippo kinases and YAP1 ina...

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Autores principales:	Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons, J. Silvio Gutkind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b930320d9074414b8a21037b5706075
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spelling	oai:doaj.org-article:1b930320d9074414b8a21037b57060752021-12-02T14:39:28ZAssembly and activation of the Hippo signalome by FAT1 tumor suppressor10.1038/s41467-018-04590-12041-1723https://doaj.org/article/1b930320d9074414b8a21037b57060752018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04590-1https://doaj.org/toc/2041-1723Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in the activation of core Hippo kinases and YAP1 inactivation.Daniel MartinMaria S. DegeseLynn Vitale-CrossRamiro Iglesias-BartolomeJuan Luis Callejas ValeraZhiyong WangXiaodong FengHuwate YeernaVachan VadmalToshiro MoroishiRick F. ThorneMoraima ZaidaBradford SiegeleSok C. CheongAlfredo A. MolinoloYardena SamuelsPablo TamayoKun Liang GuanScott M. LippmanJ. Guy LyonsJ. Silvio GutkindNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Martin Maria S. Degese Lynn Vitale-Cross Ramiro Iglesias-Bartolome Juan Luis Callejas Valera Zhiyong Wang Xiaodong Feng Huwate Yeerna Vachan Vadmal Toshiro Moroishi Rick F. Thorne Moraima Zaida Bradford Siegele Sok C. Cheong Alfredo A. Molinolo Yardena Samuels Pablo Tamayo Kun Liang Guan Scott M. Lippman J. Guy Lyons J. Silvio Gutkind Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
description	Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in the activation of core Hippo kinases and YAP1 inactivation.
format	article
author	Daniel Martin Maria S. Degese Lynn Vitale-Cross Ramiro Iglesias-Bartolome Juan Luis Callejas Valera Zhiyong Wang Xiaodong Feng Huwate Yeerna Vachan Vadmal Toshiro Moroishi Rick F. Thorne Moraima Zaida Bradford Siegele Sok C. Cheong Alfredo A. Molinolo Yardena Samuels Pablo Tamayo Kun Liang Guan Scott M. Lippman J. Guy Lyons J. Silvio Gutkind
author_facet	Daniel Martin Maria S. Degese Lynn Vitale-Cross Ramiro Iglesias-Bartolome Juan Luis Callejas Valera Zhiyong Wang Xiaodong Feng Huwate Yeerna Vachan Vadmal Toshiro Moroishi Rick F. Thorne Moraima Zaida Bradford Siegele Sok C. Cheong Alfredo A. Molinolo Yardena Samuels Pablo Tamayo Kun Liang Guan Scott M. Lippman J. Guy Lyons J. Silvio Gutkind
author_sort	Daniel Martin
title	Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
title_short	Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
title_full	Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
title_fullStr	Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
title_full_unstemmed	Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
title_sort	assembly and activation of the hippo signalome by fat1 tumor suppressor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b930320d9074414b8a21037b5706075
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Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

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