Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.

<h4>Background</h4>The World Health Organization has called for global and regional assessments of the burden of hepatitis C (HCV) along with country-specific patient profiles to better inform healthcare policy. The present investigated the characteristics and burden of patients reportin...

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Autores principales:	Marco Dacosta Dibonaventura, Yong Yuan, Benedicte Lescrauwaet, Gilbert L'italien, Gordon G Liu, Isao Kamae, Josephine A Mauskopf
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b93910a285547ecacd80557de4bad71
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spelling	oai:doaj.org-article:1b93910a285547ecacd80557de4bad712021-11-18T08:36:52ZMulticountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.1932-620310.1371/journal.pone.0086070https://doaj.org/article/1b93910a285547ecacd80557de4bad712014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465875/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The World Health Organization has called for global and regional assessments of the burden of hepatitis C (HCV) along with country-specific patient profiles to better inform healthcare policy. The present investigated the characteristics and burden of patients reporting a diagnosis of HCV infection in the US, France, Germany, Italy, Spain, the UK, urban China, and Japan using a consistent methodology of patient-reported surveys.<h4>Methods</h4>The 2010 5EU (N = 57,805), 2009 US (N = 75,000), 2008/2009 Japan (N = 37,683), and 2009/2010 urban China (N = 33,261) waves of the National Health and Wellness Survey were used as the data source. Within each country, patients with a self-reported diagnosis of HCV were compared with those who did not report a diagnosis of HCV on sociodemographics, health behaviors, comorbidities, and health outcomes (e.g., Short Form-12v2). The effect of HCV was examined using regression analysis applying sampling weights.<h4>Results</h4>The prevalence of HCV ranged from 0.26% (China) to 1.42% (Italy). Patients in Japan and Italy (61.60 and 61.02 years, respectively) were the oldest, while patients in the US were the most likely to be obese (39.31%) and have concomitant anxiety (38.43%) and depression (46.05%) compared with other countries. Pooling countries and adjusting for sociodemographics, health behaviors, and comorbidities, HCV was associated with significantly lower physical component summary scores (b = -2.51) and health utilities (b = -0.04) and greater overall work impairment (b = 8.79), physician visits (b = 2.91), and emergency department visits (b = 0.30) (all p<.05). The effects on health status were strongest in the US and UK while the effects on healthcare resource use were strongest in Japan.<h4>Conclusions</h4>HCV was associated with a significant humanistic and economic burden. These results suggest that the manifestation of the HCV burden, and the profile of the patients themselves, varied dramatically by country. Successful disease management should be cognizant of region-specific unmet needs.Marco Dacosta DibonaventuraYong YuanBenedicte LescrauwaetGilbert L'italienGordon G LiuIsao KamaeJosephine A MauskopfPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86070 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco Dacosta Dibonaventura Yong Yuan Benedicte Lescrauwaet Gilbert L'italien Gordon G Liu Isao Kamae Josephine A Mauskopf Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.
description	<h4>Background</h4>The World Health Organization has called for global and regional assessments of the burden of hepatitis C (HCV) along with country-specific patient profiles to better inform healthcare policy. The present investigated the characteristics and burden of patients reporting a diagnosis of HCV infection in the US, France, Germany, Italy, Spain, the UK, urban China, and Japan using a consistent methodology of patient-reported surveys.<h4>Methods</h4>The 2010 5EU (N = 57,805), 2009 US (N = 75,000), 2008/2009 Japan (N = 37,683), and 2009/2010 urban China (N = 33,261) waves of the National Health and Wellness Survey were used as the data source. Within each country, patients with a self-reported diagnosis of HCV were compared with those who did not report a diagnosis of HCV on sociodemographics, health behaviors, comorbidities, and health outcomes (e.g., Short Form-12v2). The effect of HCV was examined using regression analysis applying sampling weights.<h4>Results</h4>The prevalence of HCV ranged from 0.26% (China) to 1.42% (Italy). Patients in Japan and Italy (61.60 and 61.02 years, respectively) were the oldest, while patients in the US were the most likely to be obese (39.31%) and have concomitant anxiety (38.43%) and depression (46.05%) compared with other countries. Pooling countries and adjusting for sociodemographics, health behaviors, and comorbidities, HCV was associated with significantly lower physical component summary scores (b = -2.51) and health utilities (b = -0.04) and greater overall work impairment (b = 8.79), physician visits (b = 2.91), and emergency department visits (b = 0.30) (all p<.05). The effects on health status were strongest in the US and UK while the effects on healthcare resource use were strongest in Japan.<h4>Conclusions</h4>HCV was associated with a significant humanistic and economic burden. These results suggest that the manifestation of the HCV burden, and the profile of the patients themselves, varied dramatically by country. Successful disease management should be cognizant of region-specific unmet needs.
format	article
author	Marco Dacosta Dibonaventura Yong Yuan Benedicte Lescrauwaet Gilbert L'italien Gordon G Liu Isao Kamae Josephine A Mauskopf
author_facet	Marco Dacosta Dibonaventura Yong Yuan Benedicte Lescrauwaet Gilbert L'italien Gordon G Liu Isao Kamae Josephine A Mauskopf
author_sort	Marco Dacosta Dibonaventura
title	Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.
title_short	Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.
title_full	Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.
title_fullStr	Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.
title_full_unstemmed	Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.
title_sort	multicountry burden of chronic hepatitis c viral infection among those aware of their diagnosis: a patient survey.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1b93910a285547ecacd80557de4bad71
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Multicountry burden of chronic hepatitis C viral infection among those aware of their diagnosis: a patient survey.

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