The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies
Despite recent advancements in the treatment of hematologic malignancies and the emergence of newer and more sophisticated therapeutic approaches such as immunotherapy, long-term overall survival remains unsatisfactory. Metabolic alteration, as an important hallmark of cancer cells, not only contrib...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1b954460885e4a6497e089c8d7adcc322021-11-10T07:37:00ZThe Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies2234-943X10.3389/fonc.2021.767026https://doaj.org/article/1b954460885e4a6497e089c8d7adcc322021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.767026/fullhttps://doaj.org/toc/2234-943XDespite recent advancements in the treatment of hematologic malignancies and the emergence of newer and more sophisticated therapeutic approaches such as immunotherapy, long-term overall survival remains unsatisfactory. Metabolic alteration, as an important hallmark of cancer cells, not only contributes to the malignant transformation of cells, but also promotes tumor progression and metastasis. As an immune-escape mechanism, the metabolic adaptation of the bone marrow microenvironment and leukemic cells is a major player in the suppression of anti-leukemia immune responses. Therefore, metabolic rewiring in leukemia would provide promising opportunities for newer therapeutic interventions. Several therapeutic agents which affect essential bioenergetic pathways in cancer cells including glycolysis, β-oxidation of fatty acids and Krebs cycle, or anabolic pathways such as lipid biosynthesis and pentose phosphate pathway, are being tested in various types of cancers. So far, numerous preclinical or clinical trial studies using such metabolic agents alone or in combination with other remedies such as immunotherapy are in progress and have demonstrated promising outcomes. In this review, we aim to argue the importance of metabolic alterations and bioenergetic pathways in different types of leukemia and their vital roles in disease development. Designing treatments based on targeting leukemic cells vulnerabilities, particularly in nonresponsive leukemia patients, should be warranted.Mojdeh SoltaniYue ZhaoZhijia XiaMazdak Ganjalikhani HakemiAlexandr V. BazhinAlexandr V. BazhinFrontiers Media S.A.articleacute lymphocytic leukemiaacute myeloid leukemiachronic lymphocytic leukemiachronic myeloid leukemiacellular metabolismimmunometabolismNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
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| collection |
DOAJ |
| language |
EN |
| topic |
acute lymphocytic leukemia acute myeloid leukemia chronic lymphocytic leukemia chronic myeloid leukemia cellular metabolism immunometabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
acute lymphocytic leukemia acute myeloid leukemia chronic lymphocytic leukemia chronic myeloid leukemia cellular metabolism immunometabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mojdeh Soltani Yue Zhao Zhijia Xia Mazdak Ganjalikhani Hakemi Alexandr V. Bazhin Alexandr V. Bazhin The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies |
| description |
Despite recent advancements in the treatment of hematologic malignancies and the emergence of newer and more sophisticated therapeutic approaches such as immunotherapy, long-term overall survival remains unsatisfactory. Metabolic alteration, as an important hallmark of cancer cells, not only contributes to the malignant transformation of cells, but also promotes tumor progression and metastasis. As an immune-escape mechanism, the metabolic adaptation of the bone marrow microenvironment and leukemic cells is a major player in the suppression of anti-leukemia immune responses. Therefore, metabolic rewiring in leukemia would provide promising opportunities for newer therapeutic interventions. Several therapeutic agents which affect essential bioenergetic pathways in cancer cells including glycolysis, β-oxidation of fatty acids and Krebs cycle, or anabolic pathways such as lipid biosynthesis and pentose phosphate pathway, are being tested in various types of cancers. So far, numerous preclinical or clinical trial studies using such metabolic agents alone or in combination with other remedies such as immunotherapy are in progress and have demonstrated promising outcomes. In this review, we aim to argue the importance of metabolic alterations and bioenergetic pathways in different types of leukemia and their vital roles in disease development. Designing treatments based on targeting leukemic cells vulnerabilities, particularly in nonresponsive leukemia patients, should be warranted. |
| format |
article |
| author |
Mojdeh Soltani Yue Zhao Zhijia Xia Mazdak Ganjalikhani Hakemi Alexandr V. Bazhin Alexandr V. Bazhin |
| author_facet |
Mojdeh Soltani Yue Zhao Zhijia Xia Mazdak Ganjalikhani Hakemi Alexandr V. Bazhin Alexandr V. Bazhin |
| author_sort |
Mojdeh Soltani |
| title |
The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies |
| title_short |
The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies |
| title_full |
The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies |
| title_fullStr |
The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies |
| title_full_unstemmed |
The Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies |
| title_sort |
importance of cellular metabolic pathways in pathogenesis and selective treatments of hematological malignancies |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1b954460885e4a6497e089c8d7adcc32 |
| work_keys_str_mv |
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