Ultra-broadband axicon transducer for optoacoustic endoscopy

Abstract Image performance in optoacoustic endoscopy depends markedly on the design of the transducer employed. Ideally, high-resolution performance is required over an expanded depth of focus. Current optoacoustic focused transducers achieve lateral resolutions in the range of tens of microns in th...

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Autores principales:	Zakiullah Ali, Christian Zakian, Vasilis Ntziachristos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b9829a9851641d6a468cdcf9b401a82
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id	oai:doaj.org-article:1b9829a9851641d6a468cdcf9b401a82
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spelling	oai:doaj.org-article:1b9829a9851641d6a468cdcf9b401a822021-12-02T13:50:42ZUltra-broadband axicon transducer for optoacoustic endoscopy10.1038/s41598-021-81117-72045-2322https://doaj.org/article/1b9829a9851641d6a468cdcf9b401a822021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81117-7https://doaj.org/toc/2045-2322Abstract Image performance in optoacoustic endoscopy depends markedly on the design of the transducer employed. Ideally, high-resolution performance is required over an expanded depth of focus. Current optoacoustic focused transducers achieve lateral resolutions in the range of tens of microns in the mesoscopic regime, but their depth of focus is limited to hundreds of microns by the nature of their spherical geometry. We designed an ultra-broadband axicon detector with a 2 mm central aperture and investigated whether the imaging characteristics exceeded those of a spherical detector of similar size. We show a previously undocumented ability to achieve a broadband elongated pencil-beam optoacoustic sensitivity with an axicon detection geometry, providing approximately 40 μm-lateral resolution maintained over a depth of focus of 950 μm—3.8 times that of the reference spherical detector. This performance could potentially lead to optoacoustic endoscopes that can visualize optical absorption deeper and with higher resolution than any other optical endoscope today.Zakiullah AliChristian ZakianVasilis NtziachristosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zakiullah Ali Christian Zakian Vasilis Ntziachristos Ultra-broadband axicon transducer for optoacoustic endoscopy
description	Abstract Image performance in optoacoustic endoscopy depends markedly on the design of the transducer employed. Ideally, high-resolution performance is required over an expanded depth of focus. Current optoacoustic focused transducers achieve lateral resolutions in the range of tens of microns in the mesoscopic regime, but their depth of focus is limited to hundreds of microns by the nature of their spherical geometry. We designed an ultra-broadband axicon detector with a 2 mm central aperture and investigated whether the imaging characteristics exceeded those of a spherical detector of similar size. We show a previously undocumented ability to achieve a broadband elongated pencil-beam optoacoustic sensitivity with an axicon detection geometry, providing approximately 40 μm-lateral resolution maintained over a depth of focus of 950 μm—3.8 times that of the reference spherical detector. This performance could potentially lead to optoacoustic endoscopes that can visualize optical absorption deeper and with higher resolution than any other optical endoscope today.
format	article
author	Zakiullah Ali Christian Zakian Vasilis Ntziachristos
author_facet	Zakiullah Ali Christian Zakian Vasilis Ntziachristos
author_sort	Zakiullah Ali
title	Ultra-broadband axicon transducer for optoacoustic endoscopy
title_short	Ultra-broadband axicon transducer for optoacoustic endoscopy
title_full	Ultra-broadband axicon transducer for optoacoustic endoscopy
title_fullStr	Ultra-broadband axicon transducer for optoacoustic endoscopy
title_full_unstemmed	Ultra-broadband axicon transducer for optoacoustic endoscopy
title_sort	ultra-broadband axicon transducer for optoacoustic endoscopy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b9829a9851641d6a468cdcf9b401a82
work_keys_str_mv	AT zakiullahali ultrabroadbandaxicontransducerforoptoacousticendoscopy AT christianzakian ultrabroadbandaxicontransducerforoptoacousticendoscopy AT vasilisntziachristos ultrabroadbandaxicontransducerforoptoacousticendoscopy
_version_	1718392424171044864

Ultra-broadband axicon transducer for optoacoustic endoscopy

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