Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lakshmi Balagopalan, Jason Yi, Tiffany Nguyen, Katherine M. McIntire, Adam S. Harned, Kedar Narayan, Lawrence E. Samelson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b98fb09066a499aa682b8e55ae6a06f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1b98fb09066a499aa682b8e55ae6a06f
record_format	dspace
spelling	oai:doaj.org-article:1b98fb09066a499aa682b8e55ae6a06f2021-12-02T17:32:49ZPlasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation10.1038/s41467-018-04419-x2041-1723https://doaj.org/article/1b98fb09066a499aa682b8e55ae6a06f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04419-xhttps://doaj.org/toc/2041-1723Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.Lakshmi BalagopalanJason YiTiffany NguyenKatherine M. McIntireAdam S. HarnedKedar NarayanLawrence E. SamelsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lakshmi Balagopalan Jason Yi Tiffany Nguyen Katherine M. McIntire Adam S. Harned Kedar Narayan Lawrence E. Samelson Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
description	Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.
format	article
author	Lakshmi Balagopalan Jason Yi Tiffany Nguyen Katherine M. McIntire Adam S. Harned Kedar Narayan Lawrence E. Samelson
author_facet	Lakshmi Balagopalan Jason Yi Tiffany Nguyen Katherine M. McIntire Adam S. Harned Kedar Narayan Lawrence E. Samelson
author_sort	Lakshmi Balagopalan
title	Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_short	Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_full	Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_fullStr	Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_full_unstemmed	Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation
title_sort	plasma membrane lat activation precedes vesicular recruitment defining two phases of early t-cell activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b98fb09066a499aa682b8e55ae6a06f
work_keys_str_mv	AT lakshmibalagopalan plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation AT jasonyi plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation AT tiffanynguyen plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation AT katherinemmcintire plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation AT adamsharned plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation AT kedarnarayan plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation AT lawrenceesamelson plasmamembranelatactivationprecedesvesicularrecruitmentdefiningtwophasesofearlytcellactivation
_version_	1718380172179144704

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Ejemplares similares