Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants

Abstract Preterm infants with periventricular–intraventricular hemorrhage (PV–IVH) have a high risk of neurological sequelae, with severity depending on the severity of the PV–IVH. Previous studies on the pathogenesis of PV–IVH have focused mainly on comparisons of perinatal risk factors between pat...

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Autores principales:	Tian Wu, Yan Wang, Tao Xiong, Sheng Huang, Tian Tian, Jun Tang, Dezhi Mu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b9a0f61bca64000949c1fc44702a0d5
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spelling	oai:doaj.org-article:1b9a0f61bca64000949c1fc44702a0d52021-12-02T18:50:57ZRisk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants10.1038/s41598-020-70603-z2045-2322https://doaj.org/article/1b9a0f61bca64000949c1fc44702a0d52020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70603-zhttps://doaj.org/toc/2045-2322Abstract Preterm infants with periventricular–intraventricular hemorrhage (PV–IVH) have a high risk of neurological sequelae, with severity depending on the severity of the PV–IVH. Previous studies on the pathogenesis of PV–IVH have focused mainly on comparisons of perinatal risk factors between patients with and without PV–IVH. Notably, most cases of PV–IVH occur within the first 3 days after birth, and the condition may worsen within 1 week following the initial diagnosis. However, the risk factors that contribute to the deterioration of PV–IVH have not been investigated. In this cohort study, 514 PV–IVH infants with a gestational age (GA) < 32 weeks were enrolled. The dependent variable was initially diagnosed as mild PV–IVH (grade I or II) that subsequently progressed to severe PV–IVH (grade III or IV) within 1 week. A stepwise forward multivariate logistic regression model was adopted to select potential or related factors that affected the deterioration of PV–IVH in preterm infants. Overall, 42 of the 514 infants with PV–IVH (8.2%) showed deterioration within 1 week. The results showed that maternal lower genital tract infection (OR 3.73, 95% CI 1.75–7.95) was an independent risk factor for PV–IVH deterioration. Higher GA (OR 0.62, 95% CI 0.48–0.80) was a protective factor. Our results suggest that maternal lower genital tract infection and a lower GA may contribute to PV–IVH deterioration in preterm infants.Tian WuYan WangTao XiongSheng HuangTian TianJun TangDezhi MuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tian Wu Yan Wang Tao Xiong Sheng Huang Tian Tian Jun Tang Dezhi Mu Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
description	Abstract Preterm infants with periventricular–intraventricular hemorrhage (PV–IVH) have a high risk of neurological sequelae, with severity depending on the severity of the PV–IVH. Previous studies on the pathogenesis of PV–IVH have focused mainly on comparisons of perinatal risk factors between patients with and without PV–IVH. Notably, most cases of PV–IVH occur within the first 3 days after birth, and the condition may worsen within 1 week following the initial diagnosis. However, the risk factors that contribute to the deterioration of PV–IVH have not been investigated. In this cohort study, 514 PV–IVH infants with a gestational age (GA) < 32 weeks were enrolled. The dependent variable was initially diagnosed as mild PV–IVH (grade I or II) that subsequently progressed to severe PV–IVH (grade III or IV) within 1 week. A stepwise forward multivariate logistic regression model was adopted to select potential or related factors that affected the deterioration of PV–IVH in preterm infants. Overall, 42 of the 514 infants with PV–IVH (8.2%) showed deterioration within 1 week. The results showed that maternal lower genital tract infection (OR 3.73, 95% CI 1.75–7.95) was an independent risk factor for PV–IVH deterioration. Higher GA (OR 0.62, 95% CI 0.48–0.80) was a protective factor. Our results suggest that maternal lower genital tract infection and a lower GA may contribute to PV–IVH deterioration in preterm infants.
format	article
author	Tian Wu Yan Wang Tao Xiong Sheng Huang Tian Tian Jun Tang Dezhi Mu
author_facet	Tian Wu Yan Wang Tao Xiong Sheng Huang Tian Tian Jun Tang Dezhi Mu
author_sort	Tian Wu
title	Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
title_short	Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
title_full	Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
title_fullStr	Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
title_full_unstemmed	Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
title_sort	risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b9a0f61bca64000949c1fc44702a0d5
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Risk factors for the deterioration of periventricular–intraventricular hemorrhage in preterm infants

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