The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains

Abstract Clausena lansium (Lour.) Skeels seeds have been shown to have diverse beneficial medical value due to their unique active components. This study analysed the composition of essential oils (EOs) of C. lansium seeds and investigated their potential antifungal effects against Candida strains....

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Autores principales:	Yinzheng Ma, Yuanxiao Wang, Xia Zhou, Heng Yang, Huixin Zhang, Wenhan Chen, Haiying Zhang, Yunxia Zhang, Xiaowen He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b9ae04940284c588437490d9134f89b
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spelling	oai:doaj.org-article:1b9ae04940284c588437490d9134f89b2021-12-02T19:16:19ZThe influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains10.1038/s41598-021-99188-x2045-2322https://doaj.org/article/1b9ae04940284c588437490d9134f89b2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99188-xhttps://doaj.org/toc/2045-2322Abstract Clausena lansium (Lour.) Skeels seeds have been shown to have diverse beneficial medical value due to their unique active components. This study analysed the composition of essential oils (EOs) of C. lansium seeds and investigated their potential antifungal effects against Candida strains. A total of forty-six components were identified in all samples by gas chromatography-mass spectrometry (GC–MS). The main components were sabinene, β-phellandrene and 4-terpineol. Thirteen EOs of C. lansium seeds were classified into three clusters based on their components. Cluster analysis showed that the difference between the tropics and subtropics was the greatest. These EOs and the three main chemicals showed different antifungal activities against five Candida species (C. albicans, C. tropicalis, C. glabrata, C. krusei and C. parapsilosis). The antifungal activity against C. glabrata and C. krusei was higher than that against other Candida strains. EOs of C. lansium seeds displayed noteworthy antifungal activity against both sensitive and fluconazole-resistant strains, with inhibition zone diameters in the range of 9.4–23.4 mm. Comprehensive analysis illustrated the importance of sabinene, β-phellandrene and 4-terpineol to antifungal activity, and there may be some synergistic effects with other components. These results represent the first report about the correlation between the chemical composition of EOs of C. lansium seeds and antifungal activity. Taken together, the results obtained provide scientific evidence for the traditional use of C. lansium seeds waste.Yinzheng MaYuanxiao WangXia ZhouHeng YangHuixin ZhangWenhan ChenHaiying ZhangYunxia ZhangXiaowen HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yinzheng Ma Yuanxiao Wang Xia Zhou Heng Yang Huixin Zhang Wenhan Chen Haiying Zhang Yunxia Zhang Xiaowen He The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains
description	Abstract Clausena lansium (Lour.) Skeels seeds have been shown to have diverse beneficial medical value due to their unique active components. This study analysed the composition of essential oils (EOs) of C. lansium seeds and investigated their potential antifungal effects against Candida strains. A total of forty-six components were identified in all samples by gas chromatography-mass spectrometry (GC–MS). The main components were sabinene, β-phellandrene and 4-terpineol. Thirteen EOs of C. lansium seeds were classified into three clusters based on their components. Cluster analysis showed that the difference between the tropics and subtropics was the greatest. These EOs and the three main chemicals showed different antifungal activities against five Candida species (C. albicans, C. tropicalis, C. glabrata, C. krusei and C. parapsilosis). The antifungal activity against C. glabrata and C. krusei was higher than that against other Candida strains. EOs of C. lansium seeds displayed noteworthy antifungal activity against both sensitive and fluconazole-resistant strains, with inhibition zone diameters in the range of 9.4–23.4 mm. Comprehensive analysis illustrated the importance of sabinene, β-phellandrene and 4-terpineol to antifungal activity, and there may be some synergistic effects with other components. These results represent the first report about the correlation between the chemical composition of EOs of C. lansium seeds and antifungal activity. Taken together, the results obtained provide scientific evidence for the traditional use of C. lansium seeds waste.
format	article
author	Yinzheng Ma Yuanxiao Wang Xia Zhou Heng Yang Huixin Zhang Wenhan Chen Haiying Zhang Yunxia Zhang Xiaowen He
author_facet	Yinzheng Ma Yuanxiao Wang Xia Zhou Heng Yang Huixin Zhang Wenhan Chen Haiying Zhang Yunxia Zhang Xiaowen He
author_sort	Yinzheng Ma
title	The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains
title_short	The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains
title_full	The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains
title_fullStr	The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains
title_full_unstemmed	The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains
title_sort	influence of the chemical composition of essential oils of clausena lansium seeds on the growth of candida strains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b9ae04940284c588437490d9134f89b
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The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains

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