lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p

Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported as an oncogene in many tumors including retinoblastoma (RB). This research mainly focused on the functions and mechanism of MALAT1 in RB. MALAT1 was upregulated in RB tissues and cells, and it se...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhao Yuxin, Wang Zhaoxia, Gao Meili, Wang Xuehong, Feng Hui, Cui Yuanyuan, Tian Xia
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	malat1 mir-655-3p atad2 tumor progression retinoblastoma Medicine R
Acceso en línea:	https://doaj.org/article/1ba14620e00d496990f47fbc8b59bbea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1ba14620e00d496990f47fbc8b59bbea
record_format	dspace
spelling	oai:doaj.org-article:1ba14620e00d496990f47fbc8b59bbea2021-12-05T14:10:54ZlncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p2391-546310.1515/med-2021-0290https://doaj.org/article/1ba14620e00d496990f47fbc8b59bbea2021-06-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0290https://doaj.org/toc/2391-5463Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported as an oncogene in many tumors including retinoblastoma (RB). This research mainly focused on the functions and mechanism of MALAT1 in RB. MALAT1 was upregulated in RB tissues and cells, and it served as a competing endogenous RNA (ceRNA) and inhibited miRNA-655-3p (miR-655-3p) expression, which eventually regulated the expression of miR-655-3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2). The level of ATAD2 significantly increased, while that of miR-655-3p remarkably decreased in RB tissues and cells. MALAT1 depletion inhibited cell proliferation, metastasis, and epithelial–mesenchymal transition (EMT), but promoted apoptosis in vitro and blocked xenograft tumor growth in vivo. MALAT1 exerted its oncogenic functions in RB by regulating miR-655-3p/ATAD2 axis.Zhao YuxinWang ZhaoxiaGao MeiliWang XuehongFeng HuiCui YuanyuanTian XiaDe Gruyterarticlemalat1mir-655-3patad2tumor progressionretinoblastomaMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 931-943 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malat1 mir-655-3p atad2 tumor progression retinoblastoma Medicine R
spellingShingle	malat1 mir-655-3p atad2 tumor progression retinoblastoma Medicine R Zhao Yuxin Wang Zhaoxia Gao Meili Wang Xuehong Feng Hui Cui Yuanyuan Tian Xia lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
description	Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported as an oncogene in many tumors including retinoblastoma (RB). This research mainly focused on the functions and mechanism of MALAT1 in RB. MALAT1 was upregulated in RB tissues and cells, and it served as a competing endogenous RNA (ceRNA) and inhibited miRNA-655-3p (miR-655-3p) expression, which eventually regulated the expression of miR-655-3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2). The level of ATAD2 significantly increased, while that of miR-655-3p remarkably decreased in RB tissues and cells. MALAT1 depletion inhibited cell proliferation, metastasis, and epithelial–mesenchymal transition (EMT), but promoted apoptosis in vitro and blocked xenograft tumor growth in vivo. MALAT1 exerted its oncogenic functions in RB by regulating miR-655-3p/ATAD2 axis.
format	article
author	Zhao Yuxin Wang Zhaoxia Gao Meili Wang Xuehong Feng Hui Cui Yuanyuan Tian Xia
author_facet	Zhao Yuxin Wang Zhaoxia Gao Meili Wang Xuehong Feng Hui Cui Yuanyuan Tian Xia
author_sort	Zhao Yuxin
title	lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
title_short	lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
title_full	lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
title_fullStr	lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
title_full_unstemmed	lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p
title_sort	lncrna malat1 regulated atad2 to facilitate retinoblastoma progression via mir-655-3p
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/1ba14620e00d496990f47fbc8b59bbea
work_keys_str_mv	AT zhaoyuxin lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p AT wangzhaoxia lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p AT gaomeili lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p AT wangxuehong lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p AT fenghui lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p AT cuiyuanyuan lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p AT tianxia lncrnamalat1regulatedatad2tofacilitateretinoblastomaprogressionviamir6553p
_version_	1718371587163422720

lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p

Ejemplares similares