Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.
Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2009
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1ba254d4f4df43dbbfdf94462625276f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1ba254d4f4df43dbbfdf94462625276f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1ba254d4f4df43dbbfdf94462625276f2021-11-25T06:17:04ZGreen tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.1932-620310.1371/journal.pone.0004606https://doaj.org/article/1ba254d4f4df43dbbfdf94462625276f2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19242551/?tool=EBIhttps://doaj.org/toc/1932-6203Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice.Fayçal GuedjCatherine SébriéIsabelle RivalsAurelie LedruEvelyne PalyJean C BizotDesmond SmithEdward RubinBrigitte GilletMariona ArbonesJean M DelabarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 2, p e4606 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Fayçal Guedj Catherine Sébrié Isabelle Rivals Aurelie Ledru Evelyne Paly Jean C Bizot Desmond Smith Edward Rubin Brigitte Gillet Mariona Arbones Jean M Delabar Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. |
| description |
Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) - a member of a natural polyphenols family, found in great amount in green tea leaves - is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice. |
| format |
article |
| author |
Fayçal Guedj Catherine Sébrié Isabelle Rivals Aurelie Ledru Evelyne Paly Jean C Bizot Desmond Smith Edward Rubin Brigitte Gillet Mariona Arbones Jean M Delabar |
| author_facet |
Fayçal Guedj Catherine Sébrié Isabelle Rivals Aurelie Ledru Evelyne Paly Jean C Bizot Desmond Smith Edward Rubin Brigitte Gillet Mariona Arbones Jean M Delabar |
| author_sort |
Fayçal Guedj |
| title |
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. |
| title_short |
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. |
| title_full |
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. |
| title_fullStr |
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. |
| title_full_unstemmed |
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. |
| title_sort |
green tea polyphenols rescue of brain defects induced by overexpression of dyrk1a. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/1ba254d4f4df43dbbfdf94462625276f |
| work_keys_str_mv |
AT faycalguedj greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT catherinesebrie greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT isabellerivals greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT aurelieledru greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT evelynepaly greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT jeancbizot greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT desmondsmith greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT edwardrubin greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT brigittegillet greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT marionaarbones greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a AT jeanmdelabar greenteapolyphenolsrescueofbraindefectsinducedbyoverexpressionofdyrk1a |
| _version_ |
1718413968933912576 |