Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis

Abstract To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with and without Hashimoto’s thyroiditis (HT). We retrospectively reviewed the US features and status of BRAF V600E mutation in 438 consecutive patients with surg...

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Autores principales:	Qin Zhang, Bo-Ji Liu, Wei-Wei Ren, Ya-Ping He, Xiao-Long Li, Chong-Ke Zhao, Yi-Feng Zhang, Wen-Wen Yue, Jia-Yi Zheng, Hui-Xiong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ba31151e27f4031a8f5a58104307310
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spelling	oai:doaj.org-article:1ba31151e27f4031a8f5a581043073102021-12-02T16:08:19ZAssociation between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis10.1038/s41598-017-05153-y2045-2322https://doaj.org/article/1ba31151e27f4031a8f5a581043073102017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05153-yhttps://doaj.org/toc/2045-2322Abstract To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with and without Hashimoto’s thyroiditis (HT). We retrospectively reviewed the US features and status of BRAF V600E mutation in 438 consecutive patients with surgically confirmed PTCs. The association between BRAF mutation and US features were analyzed. In addition, we conducted subgroup analyses in terms of coexistent HT. The BRAF mutation was found in 86.5% of patients (379 of 438). Patient age (OR: 1.028, P = 0.010), age ≥ 50 y (OR: 1.904, P = 0.030), and microcalcification (OR: 2.262, P = 0.015) on US were significantly associated with BRAF mutation in PTC patients. Solid component (OR: 5.739, P = 0.019) on US was the significant predictor for BRAF mutation in patients with HT, while age (OR: 1.036, P = 0.017) and microcalcification (OR: 3.093, P = 0.017) were significantly associated with BRAF mutation in patients without HT. In conclusion, older age and microcalcification are risk factors for BRAF mutation in PTC patients, especially in those without HT. For those with HT, however, PTCs with BRAF mutation tend to be solid on ultrasound. These factors might be considered when making treatment planning or prognosis evaluation.Qin ZhangBo-Ji LiuWei-Wei RenYa-Ping HeXiao-Long LiChong-Ke ZhaoYi-Feng ZhangWen-Wen YueJia-Yi ZhengHui-Xiong XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qin Zhang Bo-Ji Liu Wei-Wei Ren Ya-Ping He Xiao-Long Li Chong-Ke Zhao Yi-Feng Zhang Wen-Wen Yue Jia-Yi Zheng Hui-Xiong Xu Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis
description	Abstract To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with and without Hashimoto’s thyroiditis (HT). We retrospectively reviewed the US features and status of BRAF V600E mutation in 438 consecutive patients with surgically confirmed PTCs. The association between BRAF mutation and US features were analyzed. In addition, we conducted subgroup analyses in terms of coexistent HT. The BRAF mutation was found in 86.5% of patients (379 of 438). Patient age (OR: 1.028, P = 0.010), age ≥ 50 y (OR: 1.904, P = 0.030), and microcalcification (OR: 2.262, P = 0.015) on US were significantly associated with BRAF mutation in PTC patients. Solid component (OR: 5.739, P = 0.019) on US was the significant predictor for BRAF mutation in patients with HT, while age (OR: 1.036, P = 0.017) and microcalcification (OR: 3.093, P = 0.017) were significantly associated with BRAF mutation in patients without HT. In conclusion, older age and microcalcification are risk factors for BRAF mutation in PTC patients, especially in those without HT. For those with HT, however, PTCs with BRAF mutation tend to be solid on ultrasound. These factors might be considered when making treatment planning or prognosis evaluation.
format	article
author	Qin Zhang Bo-Ji Liu Wei-Wei Ren Ya-Ping He Xiao-Long Li Chong-Ke Zhao Yi-Feng Zhang Wen-Wen Yue Jia-Yi Zheng Hui-Xiong Xu
author_facet	Qin Zhang Bo-Ji Liu Wei-Wei Ren Ya-Ping He Xiao-Long Li Chong-Ke Zhao Yi-Feng Zhang Wen-Wen Yue Jia-Yi Zheng Hui-Xiong Xu
author_sort	Qin Zhang
title	Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis
title_short	Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis
title_full	Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis
title_fullStr	Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis
title_full_unstemmed	Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis
title_sort	association between braf v600e mutation and ultrasound features in papillary thyroid carcinoma patients with and without hashimoto’s thyroiditis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ba31151e27f4031a8f5a58104307310
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Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto’s Thyroiditis

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