Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients

Abstract Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 conse...

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Autores principales:	Su Hwan Lee, Kyu Ha Huh, Dong Jin Joo, Myoung Soo Kim, Soon Il Kim, Juhan Lee, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Yu Seun Kim, Song Yee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ba449d057dc46658cf71bda88a89cc0
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spelling	oai:doaj.org-article:1ba449d057dc46658cf71bda88a89cc02021-12-02T11:41:11ZRisk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients10.1038/s41598-017-01818-w2045-2322https://doaj.org/article/1ba449d057dc46658cf71bda88a89cc02017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01818-whttps://doaj.org/toc/2045-2322Abstract Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants performed at Severance Hospital between April 2011 and April 2014. Eighteen kidney transplantation recipients (3.6%) were diagnosed with PJP. In the univariate analysis, acute graft rejection, CMV infection, use of medication for diabetes mellitus, and lowest lymphocyte count were associated with PJP. Recipients who experienced acute graft rejection (odds ratio [OR] 11.81, 95% confidence interval [CI] 3.06–45.57, P < 0.001) or developed CMV infection (OR 5.42, 95% CI 1.69–17.39, P = 0.005) had high odds of PJP in multivariate analysis. In the acute graft rejection subgroup, patients treated with anti-thymocyte globulin (ATG) had significantly higher odds of PJP (OR 5.25, 95% CI 1.01–27.36, P = 0.006) than those who were not. Our data suggest that acute graft rejection and CMV infection may be risk factors for PJP in kidney transplant patients. The use of ATG for acute graft rejection may increase the risk of PJP.Su Hwan LeeKyu Ha HuhDong Jin JooMyoung Soo KimSoon Il KimJuhan LeeMoo Suk ParkYoung Sam KimSe Kyu KimJoon ChangYu Seun KimSong Yee KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Su Hwan Lee Kyu Ha Huh Dong Jin Joo Myoung Soo Kim Soon Il Kim Juhan Lee Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Yu Seun Kim Song Yee Kim Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients
description	Abstract Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants performed at Severance Hospital between April 2011 and April 2014. Eighteen kidney transplantation recipients (3.6%) were diagnosed with PJP. In the univariate analysis, acute graft rejection, CMV infection, use of medication for diabetes mellitus, and lowest lymphocyte count were associated with PJP. Recipients who experienced acute graft rejection (odds ratio [OR] 11.81, 95% confidence interval [CI] 3.06–45.57, P < 0.001) or developed CMV infection (OR 5.42, 95% CI 1.69–17.39, P = 0.005) had high odds of PJP in multivariate analysis. In the acute graft rejection subgroup, patients treated with anti-thymocyte globulin (ATG) had significantly higher odds of PJP (OR 5.25, 95% CI 1.01–27.36, P = 0.006) than those who were not. Our data suggest that acute graft rejection and CMV infection may be risk factors for PJP in kidney transplant patients. The use of ATG for acute graft rejection may increase the risk of PJP.
format	article
author	Su Hwan Lee Kyu Ha Huh Dong Jin Joo Myoung Soo Kim Soon Il Kim Juhan Lee Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Yu Seun Kim Song Yee Kim
author_facet	Su Hwan Lee Kyu Ha Huh Dong Jin Joo Myoung Soo Kim Soon Il Kim Juhan Lee Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Yu Seun Kim Song Yee Kim
author_sort	Su Hwan Lee
title	Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients
title_short	Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients
title_full	Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients
title_fullStr	Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients
title_full_unstemmed	Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients
title_sort	risk factors for pneumocystis jirovecii pneumonia (pjp) in kidney transplantation recipients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ba449d057dc46658cf71bda88a89cc0
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Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients

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