Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients

Abstract Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose o...

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Autores principales:	Mei-Yun Wu, Wei-Xiong Lim, Yu-Fan Cheng, Ching-Di Chang, Hsien-Wen Hsu, Chih-Che Lin, Chao-Long Chen, Wan-Ching Chang, Chun-Yen Yu, Leo Leung-Chit Tsang, Yi-Hsuan Chuang, Hsin-You Ou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ba8d145a0c74c419129d1af2b2c59c1
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spelling	oai:doaj.org-article:1ba8d145a0c74c419129d1af2b2c59c12021-12-02T17:18:22ZSarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients10.1038/s41598-021-98399-62045-2322https://doaj.org/article/1ba8d145a0c74c419129d1af2b2c59c12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98399-6https://doaj.org/toc/2045-2322Abstract Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship between sarcopenia and significant surgical complications in LDLT recipients. This retrospective review included patients who had received LDLT at our institute from 2005 to 2017. Sarcopenia was assessed using the psoas muscle index (PMI) in cross-sectional images. ROC curve analysis was used to determine the ability of PMI to predict postoperative complications. Correlations between major postoperative complications and sarcopenia were evaluated using regression analysis. A total of 271 LDLT recipients were included. No significant differences were found between PMI and major postoperative complications in male patients. Female recipients with major postoperative complications had significantly lower mean PMI values (P = 0.028), and the PMI cut-off value was 2.63 cm2/m2. Postoperative massive pleural effusion requiring pigtail drainage occurred more frequently in the sarcopenia group than in the non-sarcopenia group (P = 0.003). 1-, 3-, 5- and 10-year overall survival rates in female were significantly poorer in the sarcopenia group (n = 14) compared with the non-sarcopenia group (n = 108), at 92.9% versus 97.2%, 85.7% versus 95.4%, 85.7% versus 92.5% and 70.1 versus 82.0%, respectively (P = 0.041) and 94.6%, 89.9%, 85.9% and 78.5% in male patients. Sarcopenia is associated with a significantly higher risk of major postoperative complications in females. PMI and sarcopenia together are predictive of major postoperative complications and survival rates in female LDLT recipients.Mei-Yun WuWei-Xiong LimYu-Fan ChengChing-Di ChangHsien-Wen HsuChih-Che LinChao-Long ChenWan-Ching ChangChun-Yen YuLeo Leung-Chit TsangYi-Hsuan ChuangHsin-You OuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mei-Yun Wu Wei-Xiong Lim Yu-Fan Cheng Ching-Di Chang Hsien-Wen Hsu Chih-Che Lin Chao-Long Chen Wan-Ching Chang Chun-Yen Yu Leo Leung-Chit Tsang Yi-Hsuan Chuang Hsin-You Ou Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
description	Abstract Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship between sarcopenia and significant surgical complications in LDLT recipients. This retrospective review included patients who had received LDLT at our institute from 2005 to 2017. Sarcopenia was assessed using the psoas muscle index (PMI) in cross-sectional images. ROC curve analysis was used to determine the ability of PMI to predict postoperative complications. Correlations between major postoperative complications and sarcopenia were evaluated using regression analysis. A total of 271 LDLT recipients were included. No significant differences were found between PMI and major postoperative complications in male patients. Female recipients with major postoperative complications had significantly lower mean PMI values (P = 0.028), and the PMI cut-off value was 2.63 cm2/m2. Postoperative massive pleural effusion requiring pigtail drainage occurred more frequently in the sarcopenia group than in the non-sarcopenia group (P = 0.003). 1-, 3-, 5- and 10-year overall survival rates in female were significantly poorer in the sarcopenia group (n = 14) compared with the non-sarcopenia group (n = 108), at 92.9% versus 97.2%, 85.7% versus 95.4%, 85.7% versus 92.5% and 70.1 versus 82.0%, respectively (P = 0.041) and 94.6%, 89.9%, 85.9% and 78.5% in male patients. Sarcopenia is associated with a significantly higher risk of major postoperative complications in females. PMI and sarcopenia together are predictive of major postoperative complications and survival rates in female LDLT recipients.
format	article
author	Mei-Yun Wu Wei-Xiong Lim Yu-Fan Cheng Ching-Di Chang Hsien-Wen Hsu Chih-Che Lin Chao-Long Chen Wan-Ching Chang Chun-Yen Yu Leo Leung-Chit Tsang Yi-Hsuan Chuang Hsin-You Ou
author_facet	Mei-Yun Wu Wei-Xiong Lim Yu-Fan Cheng Ching-Di Chang Hsien-Wen Hsu Chih-Che Lin Chao-Long Chen Wan-Ching Chang Chun-Yen Yu Leo Leung-Chit Tsang Yi-Hsuan Chuang Hsin-You Ou
author_sort	Mei-Yun Wu
title	Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
title_short	Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
title_full	Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
title_fullStr	Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
title_full_unstemmed	Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
title_sort	sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ba8d145a0c74c419129d1af2b2c59c1
work_keys_str_mv	AT meiyunwu sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT weixionglim sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT yufancheng sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT chingdichang sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT hsienwenhsu sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT chihchelin sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT chaolongchen sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT wanchingchang sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT chunyenyu sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT leoleungchittsang sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT yihsuanchuang sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients AT hsinyouou sarcopeniaadverselyimpactspostoperativecomplicationsinlivingdonorlivertransplantationrecipients
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Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients

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