Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial

Arno Kerling,1 Dagmar Hartung,2 Brendon Stubbs,3,4 Momme Kück,1 Uwe Tegtbur,1 Lena Grams,1 Thomas Sanjay Weber-Spickschen,1 Kai G Kahl5 1Institute of Sport Medicine, Hannover Medical School, Hannover, Germany; 2Institute for Diagnostic and Interventional Radiology, Hannover Medical School,...

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Autores principales:	Kerling A, Hartung D, Stubbs B, Kück M, Tegtbur U, Grams L, Weber-Spickschen TS, Kahl KG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Muscle mass depression sarcopenia aerobic exercise Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1bab88d081104bb3abb5729eea65aad8
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spelling	oai:doaj.org-article:1bab88d081104bb3abb5729eea65aad82021-12-02T09:05:04ZImpact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial1178-2021https://doaj.org/article/1bab88d081104bb3abb5729eea65aad82018-08-01T00:00:00Zhttps://www.dovepress.com/impact-of-aerobic-exercise-on-muscle-mass-in-patients-with-major-depre-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Arno Kerling,1 Dagmar Hartung,2 Brendon Stubbs,3,4 Momme Kück,1 Uwe Tegtbur,1 Lena Grams,1 Thomas Sanjay Weber-Spickschen,1 Kai G Kahl5 1Institute of Sport Medicine, Hannover Medical School, Hannover, Germany; 2Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany; 3Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK; 4Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, UK; 5Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany Objective: Sarcopenia leads to physical function impairment and at least to increasing all-cause mortality. There are notes on reduced muscle mass in patients with major depressive disorder (MDD). Whether an exercise intervention counteracts low muscle mass in patients with MDD has not been studied so far. Therefore, our study aimed at examining effects of regular aerobic exercise training on muscle mass in patients with MDD. Participants and methods: Thirty inpatients with MDD were included in the study, of which 20 received an additional supervised exercise program. Ten patients obtained treatment as usual. Muscle mass was measured using MRI before and 6 weeks after the training period (3 times per week for 45 minutes). Results: We found a significant effect of the exercise intervention on the amount of muscle mass depending on age, body mass index, and the physical activity score (P=0.042). Conclusion: Among other positive effects, regular exercise increases muscle mass in patients with MDD and, therefore, should be recommended as an additional treatment tool. Keywords: muscle mass, depression, sarcopenia, aerobic exerciseKerling AHartung DStubbs BKück MTegtbur UGrams LWeber-Spickschen TSKahl KGDove Medical PressarticleMuscle massdepressionsarcopeniaaerobic exerciseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1969-1974 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Muscle mass depression sarcopenia aerobic exercise Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Muscle mass depression sarcopenia aerobic exercise Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kerling A Hartung D Stubbs B Kück M Tegtbur U Grams L Weber-Spickschen TS Kahl KG Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
description	Arno Kerling,1 Dagmar Hartung,2 Brendon Stubbs,3,4 Momme Kück,1 Uwe Tegtbur,1 Lena Grams,1 Thomas Sanjay Weber-Spickschen,1 Kai G Kahl5 1Institute of Sport Medicine, Hannover Medical School, Hannover, Germany; 2Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany; 3Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK; 4Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, UK; 5Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany Objective: Sarcopenia leads to physical function impairment and at least to increasing all-cause mortality. There are notes on reduced muscle mass in patients with major depressive disorder (MDD). Whether an exercise intervention counteracts low muscle mass in patients with MDD has not been studied so far. Therefore, our study aimed at examining effects of regular aerobic exercise training on muscle mass in patients with MDD. Participants and methods: Thirty inpatients with MDD were included in the study, of which 20 received an additional supervised exercise program. Ten patients obtained treatment as usual. Muscle mass was measured using MRI before and 6 weeks after the training period (3 times per week for 45 minutes). Results: We found a significant effect of the exercise intervention on the amount of muscle mass depending on age, body mass index, and the physical activity score (P=0.042). Conclusion: Among other positive effects, regular exercise increases muscle mass in patients with MDD and, therefore, should be recommended as an additional treatment tool. Keywords: muscle mass, depression, sarcopenia, aerobic exercise
format	article
author	Kerling A Hartung D Stubbs B Kück M Tegtbur U Grams L Weber-Spickschen TS Kahl KG
author_facet	Kerling A Hartung D Stubbs B Kück M Tegtbur U Grams L Weber-Spickschen TS Kahl KG
author_sort	Kerling A
title	Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
title_short	Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
title_full	Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
title_fullStr	Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
title_full_unstemmed	Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
title_sort	impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1bab88d081104bb3abb5729eea65aad8
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_version_	1718398228659961856

Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial

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