Methodology and applicability of the human contact burn injury model: A systematic review.

The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent regarding essential methodological variables, challenging th...

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Autores principales:	Anders Deichmann Springborg, Caitlin Rae Wessel, Lars Peter Kloster Andersen, Mads Utke Werner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1bb1726fe13544dc97e616e846026361
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spelling	oai:doaj.org-article:1bb1726fe13544dc97e616e8460263612021-12-02T20:08:51ZMethodology and applicability of the human contact burn injury model: A systematic review.1932-620310.1371/journal.pone.0254790https://doaj.org/article/1bb1726fe13544dc97e616e8460263612021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254790https://doaj.org/toc/1932-6203The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent regarding essential methodological variables, challenging the validity of the model. This systematic review analyzes methodologies, outcomes, and research applications of the contact burn injury model. Based on these results, we propose an improved contact burn injury testing paradigm. A literature search was conducted (15-JUL-2020) using PubMed, EMBASE, Web of Science, and Google Scholar. Sixty-four studies were included. The contact burn injury model induced consistent levels of primary and secondary hyperalgesia. However, the analyses revealed variations in the methodology of the contact burn injury heating paradigm and the post-burn application of test stimuli. The contact burn injury model had limited testing sensitivity in demonstrating analgesic efficacy. There was a weak correlation between experimental and clinical pain intensity variables. The data analysis was limited by the methodological heterogenicity of the different studies and a high risk of bias across the studies. In conclusion, although the contact burn injury model provides robust hyperalgesia, it has limited efficacy in testing analgesic drug response. Recommendations for future use of the model are being provided, but further research is needed to improve the sensitivity of the contact burn injury method. The protocol for this review has been published in PROSPERO (ID: CRD42019133734).Anders Deichmann SpringborgCaitlin Rae WesselLars Peter Kloster AndersenMads Utke WernerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254790 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anders Deichmann Springborg Caitlin Rae Wessel Lars Peter Kloster Andersen Mads Utke Werner Methodology and applicability of the human contact burn injury model: A systematic review.
description	The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent regarding essential methodological variables, challenging the validity of the model. This systematic review analyzes methodologies, outcomes, and research applications of the contact burn injury model. Based on these results, we propose an improved contact burn injury testing paradigm. A literature search was conducted (15-JUL-2020) using PubMed, EMBASE, Web of Science, and Google Scholar. Sixty-four studies were included. The contact burn injury model induced consistent levels of primary and secondary hyperalgesia. However, the analyses revealed variations in the methodology of the contact burn injury heating paradigm and the post-burn application of test stimuli. The contact burn injury model had limited testing sensitivity in demonstrating analgesic efficacy. There was a weak correlation between experimental and clinical pain intensity variables. The data analysis was limited by the methodological heterogenicity of the different studies and a high risk of bias across the studies. In conclusion, although the contact burn injury model provides robust hyperalgesia, it has limited efficacy in testing analgesic drug response. Recommendations for future use of the model are being provided, but further research is needed to improve the sensitivity of the contact burn injury method. The protocol for this review has been published in PROSPERO (ID: CRD42019133734).
format	article
author	Anders Deichmann Springborg Caitlin Rae Wessel Lars Peter Kloster Andersen Mads Utke Werner
author_facet	Anders Deichmann Springborg Caitlin Rae Wessel Lars Peter Kloster Andersen Mads Utke Werner
author_sort	Anders Deichmann Springborg
title	Methodology and applicability of the human contact burn injury model: A systematic review.
title_short	Methodology and applicability of the human contact burn injury model: A systematic review.
title_full	Methodology and applicability of the human contact burn injury model: A systematic review.
title_fullStr	Methodology and applicability of the human contact burn injury model: A systematic review.
title_full_unstemmed	Methodology and applicability of the human contact burn injury model: A systematic review.
title_sort	methodology and applicability of the human contact burn injury model: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1bb1726fe13544dc97e616e846026361
work_keys_str_mv	AT andersdeichmannspringborg methodologyandapplicabilityofthehumancontactburninjurymodelasystematicreview AT caitlinraewessel methodologyandapplicabilityofthehumancontactburninjurymodelasystematicreview AT larspeterklosterandersen methodologyandapplicabilityofthehumancontactburninjurymodelasystematicreview AT madsutkewerner methodologyandapplicabilityofthehumancontactburninjurymodelasystematicreview
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Methodology and applicability of the human contact burn injury model: A systematic review.

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