Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends

Abstract Since the development of the first vascular grafts, fabrication of vessel replacements with diameters smaller than 6 mm remains a challenge. The present work aimed to develop PVA (poly (vinyl alcohol))-gelatin hybrids as tubes suitable for replacement of very small vessels and to evaluate t...

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Autores principales:	M. Atlan, T. Simon-Yarza, J. M. Ino, V. Hunsinger, L. Corté, P. Ou, R. Aid-Launais, M. Chaouat, D. Letourneur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1bb1f2af80a64e7eae89f9203ee1b739
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spelling	oai:doaj.org-article:1bb1f2af80a64e7eae89f9203ee1b7392021-12-02T12:32:47ZDesign, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends10.1038/s41598-018-25703-22045-2322https://doaj.org/article/1bb1f2af80a64e7eae89f9203ee1b7392018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25703-2https://doaj.org/toc/2045-2322Abstract Since the development of the first vascular grafts, fabrication of vessel replacements with diameters smaller than 6 mm remains a challenge. The present work aimed to develop PVA (poly (vinyl alcohol))-gelatin hybrids as tubes suitable for replacement of very small vessels and to evaluate their performance using a rat abdominal aorta interposition model. PVA-gelatin hybrid tubes with internal and external diameters of 1.4 mm and 1.8 mm, respectively, composed of 4 different gelatin ratios were prepared using a one-step strategy with both chemical and physical crosslinking. By 3D Time of Flight MRI, Doppler-Ultrasound, Computed Tomography angiography and histology, we demonstrated good patency rates with the 1% gelatin composition until the end of the study at 3 months (50% compared to 0% of PVA control grafts). A reduction of the patency rate during the time of implantation suggested some loss of properties of the hybrid material in vivo, further confirmed by mechanical evaluation until one year. In particular, stiffening and reduction of compliance of the PVA-gelatin grafts was demonstrated, which might explain the observed long-term changes in patency rate. These encouraging results confirm the potential of PVA-gelatin hybrids as ready-to-use vascular grafts for very small vessel replacement.M. AtlanT. Simon-YarzaJ. M. InoV. HunsingerL. CortéP. OuR. Aid-LaunaisM. ChaouatD. LetourneurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Atlan T. Simon-Yarza J. M. Ino V. Hunsinger L. Corté P. Ou R. Aid-Launais M. Chaouat D. Letourneur Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
description	Abstract Since the development of the first vascular grafts, fabrication of vessel replacements with diameters smaller than 6 mm remains a challenge. The present work aimed to develop PVA (poly (vinyl alcohol))-gelatin hybrids as tubes suitable for replacement of very small vessels and to evaluate their performance using a rat abdominal aorta interposition model. PVA-gelatin hybrid tubes with internal and external diameters of 1.4 mm and 1.8 mm, respectively, composed of 4 different gelatin ratios were prepared using a one-step strategy with both chemical and physical crosslinking. By 3D Time of Flight MRI, Doppler-Ultrasound, Computed Tomography angiography and histology, we demonstrated good patency rates with the 1% gelatin composition until the end of the study at 3 months (50% compared to 0% of PVA control grafts). A reduction of the patency rate during the time of implantation suggested some loss of properties of the hybrid material in vivo, further confirmed by mechanical evaluation until one year. In particular, stiffening and reduction of compliance of the PVA-gelatin grafts was demonstrated, which might explain the observed long-term changes in patency rate. These encouraging results confirm the potential of PVA-gelatin hybrids as ready-to-use vascular grafts for very small vessel replacement.
format	article
author	M. Atlan T. Simon-Yarza J. M. Ino V. Hunsinger L. Corté P. Ou R. Aid-Launais M. Chaouat D. Letourneur
author_facet	M. Atlan T. Simon-Yarza J. M. Ino V. Hunsinger L. Corté P. Ou R. Aid-Launais M. Chaouat D. Letourneur
author_sort	M. Atlan
title	Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
title_short	Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
title_full	Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
title_fullStr	Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
title_full_unstemmed	Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends
title_sort	design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of pva-gelatin blends
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1bb1f2af80a64e7eae89f9203ee1b739
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Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends

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