Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology

Objective: To explore the potential antidepressant mechanism of Wenyang Jieyu Granules with multiple targets and components based on network pharmacology, and to verify the cAMP pathway and animal experimental results. Methods: The active components of Aconitum, Guizhi, Glycyrrhiza uralensis, Wum...

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Autores principales:	Min Shi, Jian-Ping Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Editorial Board of Journal of Hainan Medical University 2021
Materias:	wenyang jieyu granule depression network pharmacology target molecular docking Medicine R
Acceso en línea:	https://doaj.org/article/1bb27474cdf64e84985746b1c0fc4aab
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spelling	oai:doaj.org-article:1bb27474cdf64e84985746b1c0fc4aab2021-12-01T05:15:29ZStudy on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology1007-1237https://doaj.org/article/1bb27474cdf64e84985746b1c0fc4aab2021-10-01T00:00:00Zhttp://www.hnykdxxb.com/PDF/202120/07.pdfhttps://doaj.org/toc/1007-1237Objective: To explore the potential antidepressant mechanism of Wenyang Jieyu Granules with multiple targets and components based on network pharmacology, and to verify the cAMP pathway and animal experimental results. Methods: The active components of Aconitum, Guizhi, Glycyrrhiza uralensis, Wumei, Jujube and Ginger in Wenyang Jieyu Granules were searched and screened by TCM System Pharmacology Analysis Platform (TCMSP). Using the Swiss database to predict its target, and then through the UniProt database to query the target corresponding genes; with the use of Gene Cards、OMIM database query depression related target Point and gene mapping to get the potential target of Wenyang Jieyu granule antidepressant. using Cytoscape, String software to plot the "wenyangjieyu granule-active component-potential action target-depression" network and "protein interaction network ", and using David database for GO functional enrichment analysis and KEGG pathway enrichment analysis to predict the action mechanism of wenyangjieyu granule in the treatment of depression and verify it with some previous relevant experimental results. Autodock software was used to perform molecular docking experiments on selected components and targets. Results: The topology analysis is effective there are 47 core components of depression, and 40 potential key targets are SLC6A2, SHBG, ACHE, NR3C1, ESR1. they are involved in many biological processes, such as neurotransmitter receptor conduction, ammonium ion binding, postsynaptic neurotransmitter receptor activity, G protein-coupled neurotransmitter receptor activity. they play an antidepressant effect through brain tissue nerve activity ligand-receptor interaction signaling pathway, cAMP, PI3K-Akt, MAPK signaling pathway, ErbB signaling pathway, etc. At the same time, the results of molecular docking show that the core components have good binding force to the key targets. Conclusion: Wenyang Jieyu granule. The active components of the anti-depressant effect are mediated by multiple signaling pathways and multiple targets.Min ShiJian-Ping ZhaoEditorial Board of Journal of Hainan Medical Universityarticlewenyang jieyu granuledepressionnetwork pharmacologytarget molecular dockingMedicineRENJournal of Hainan Medical University, Vol 27, Iss 20, Pp 30-36 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	wenyang jieyu granule depression network pharmacology target molecular docking Medicine R
spellingShingle	wenyang jieyu granule depression network pharmacology target molecular docking Medicine R Min Shi Jian-Ping Zhao Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology
description	Objective: To explore the potential antidepressant mechanism of Wenyang Jieyu Granules with multiple targets and components based on network pharmacology, and to verify the cAMP pathway and animal experimental results. Methods: The active components of Aconitum, Guizhi, Glycyrrhiza uralensis, Wumei, Jujube and Ginger in Wenyang Jieyu Granules were searched and screened by TCM System Pharmacology Analysis Platform (TCMSP). Using the Swiss database to predict its target, and then through the UniProt database to query the target corresponding genes; with the use of Gene Cards、OMIM database query depression related target Point and gene mapping to get the potential target of Wenyang Jieyu granule antidepressant. using Cytoscape, String software to plot the "wenyangjieyu granule-active component-potential action target-depression" network and "protein interaction network ", and using David database for GO functional enrichment analysis and KEGG pathway enrichment analysis to predict the action mechanism of wenyangjieyu granule in the treatment of depression and verify it with some previous relevant experimental results. Autodock software was used to perform molecular docking experiments on selected components and targets. Results: The topology analysis is effective there are 47 core components of depression, and 40 potential key targets are SLC6A2, SHBG, ACHE, NR3C1, ESR1. they are involved in many biological processes, such as neurotransmitter receptor conduction, ammonium ion binding, postsynaptic neurotransmitter receptor activity, G protein-coupled neurotransmitter receptor activity. they play an antidepressant effect through brain tissue nerve activity ligand-receptor interaction signaling pathway, cAMP, PI3K-Akt, MAPK signaling pathway, ErbB signaling pathway, etc. At the same time, the results of molecular docking show that the core components have good binding force to the key targets. Conclusion: Wenyang Jieyu granule. The active components of the anti-depressant effect are mediated by multiple signaling pathways and multiple targets.
format	article
author	Min Shi Jian-Ping Zhao
author_facet	Min Shi Jian-Ping Zhao
author_sort	Min Shi
title	Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology
title_short	Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology
title_full	Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology
title_fullStr	Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology
title_full_unstemmed	Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology
title_sort	study on the mechanism of wenyang jieyu granules in the treatment of depression based on network pharmacology
publisher	Editorial Board of Journal of Hainan Medical University
publishDate	2021
url	https://doaj.org/article/1bb27474cdf64e84985746b1c0fc4aab
work_keys_str_mv	AT minshi studyonthemechanismofwenyangjieyugranulesinthetreatmentofdepressionbasedonnetworkpharmacology AT jianpingzhao studyonthemechanismofwenyangjieyugranulesinthetreatmentofdepressionbasedonnetworkpharmacology
_version_	1718405526343122944

Study on the mechanism of Wenyang Jieyu Granules in the treatment of depression based on network pharmacology

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