Inflammatory mechanisms in the lung

B Moldoveanu1, P Otmishi1, P Jani1, J Walker1,2, X Sarmiento3, J Guardiola1, M Saad1, Jerry Yu11Department of Medicine, University of Louisville, Louisville, KY, USA, 40292; 2Department of Respiratory Therapy, Bellarmine University, Louisville, KY, USA, 40205; 3Intensive Care Medicine Service, Unive...

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Autores principales:	B Moldoveanu, P Otmishi, P Jani, J Walker, X Sarmiento, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1bb4b9bf234d4233a24d806e282a3a2f
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spelling	oai:doaj.org-article:1bb4b9bf234d4233a24d806e282a3a2f2021-12-02T01:57:03ZInflammatory mechanisms in the lung1178-7031https://doaj.org/article/1bb4b9bf234d4233a24d806e282a3a2f2008-12-01T00:00:00Zhttp://www.dovepress.com/inflammatory-mechanisms-in-the-lung-a2722https://doaj.org/toc/1178-7031B Moldoveanu1, P Otmishi1, P Jani1, J Walker1,2, X Sarmiento3, J Guardiola1, M Saad1, Jerry Yu11Department of Medicine, University of Louisville, Louisville, KY, USA, 40292; 2Department of Respiratory Therapy, Bellarmine University, Louisville, KY, USA, 40205; 3Intensive Care Medicine Service, University Hospital Germans Trias i Pujol, Badalona, Spain 08916Abstract: Inflammation is the body&rsquo;s response to insults, which include infection, trauma, and hypersensitivity. The inflammatory response is complex and involves a variety of mechanisms to defend against pathogens and repair tissue. In the lung, inflammation is usually caused by pathogens or by exposure to toxins, pollutants, irritants, and allergens. During inflammation, numerous types of inflammatory cells are activated. Each releases cytokines and mediators to modify activities of other inflammatory cells. Orchestration of these cells and molecules leads to progression of inflammation. Clinically, acute inflammation is seen in pneumonia and acute respiratory distress syndrome (ARDS), whereas chronic inflammation is represented by asthma and chronic obstructive pulmonary disease (COPD). Because the lung is a vital organ for gas exchange, excessive inflammation can be life threatening. Because the lung is constantly exposed to harmful pathogens, an immediate and intense defense action (mainly inflammation) is required to eliminate the invaders as early as possible. A delicate balance between inflammation and anti-inflammation is essential for lung homeostasis. A full understanding of the underlying mechanisms is vital in the treatment of patients with lung inflammation. This review focuses on cellular and molecular aspects of lung inflammation during acute and chronic inflammatory states.Keywords: inflammation, lung, inflammatory mediators, cytokines B MoldoveanuP OtmishiP JaniJ WalkerX Sarmientoet alDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2009, Iss default, Pp 1-11 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 B Moldoveanu P Otmishi P Jani J Walker X Sarmiento et al Inflammatory mechanisms in the lung
description	B Moldoveanu1, P Otmishi1, P Jani1, J Walker1,2, X Sarmiento3, J Guardiola1, M Saad1, Jerry Yu11Department of Medicine, University of Louisville, Louisville, KY, USA, 40292; 2Department of Respiratory Therapy, Bellarmine University, Louisville, KY, USA, 40205; 3Intensive Care Medicine Service, University Hospital Germans Trias i Pujol, Badalona, Spain 08916Abstract: Inflammation is the body&rsquo;s response to insults, which include infection, trauma, and hypersensitivity. The inflammatory response is complex and involves a variety of mechanisms to defend against pathogens and repair tissue. In the lung, inflammation is usually caused by pathogens or by exposure to toxins, pollutants, irritants, and allergens. During inflammation, numerous types of inflammatory cells are activated. Each releases cytokines and mediators to modify activities of other inflammatory cells. Orchestration of these cells and molecules leads to progression of inflammation. Clinically, acute inflammation is seen in pneumonia and acute respiratory distress syndrome (ARDS), whereas chronic inflammation is represented by asthma and chronic obstructive pulmonary disease (COPD). Because the lung is a vital organ for gas exchange, excessive inflammation can be life threatening. Because the lung is constantly exposed to harmful pathogens, an immediate and intense defense action (mainly inflammation) is required to eliminate the invaders as early as possible. A delicate balance between inflammation and anti-inflammation is essential for lung homeostasis. A full understanding of the underlying mechanisms is vital in the treatment of patients with lung inflammation. This review focuses on cellular and molecular aspects of lung inflammation during acute and chronic inflammatory states.Keywords: inflammation, lung, inflammatory mediators, cytokines
format	article
author	B Moldoveanu P Otmishi P Jani J Walker X Sarmiento et al
author_facet	B Moldoveanu P Otmishi P Jani J Walker X Sarmiento et al
author_sort	B Moldoveanu
title	Inflammatory mechanisms in the lung
title_short	Inflammatory mechanisms in the lung
title_full	Inflammatory mechanisms in the lung
title_fullStr	Inflammatory mechanisms in the lung
title_full_unstemmed	Inflammatory mechanisms in the lung
title_sort	inflammatory mechanisms in the lung
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/1bb4b9bf234d4233a24d806e282a3a2f
work_keys_str_mv	AT bmoldoveanu inflammatorymechanismsinthelung AT potmishi inflammatorymechanismsinthelung AT pjani inflammatorymechanismsinthelung AT jwalker inflammatorymechanismsinthelung AT xsarmiento inflammatorymechanismsinthelung AT etal inflammatorymechanismsinthelung
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Inflammatory mechanisms in the lung

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