Next generation plasma proteome profiling to monitor health and disease

The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.

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Detalles Bibliográficos
Autores principales: Wen Zhong, Fredrik Edfors, Anders Gummesson, Göran Bergström, Linn Fagerberg, Mathias Uhlén
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1bbb3cacc2fd454eb90474d2d27c313f
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Descripción
Sumario:The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.