Next generation plasma proteome profiling to monitor health and disease

The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.

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Autores principales:	Wen Zhong, Fredrik Edfors, Anders Gummesson, Göran Bergström, Linn Fagerberg, Mathias Uhlén
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bbb3cacc2fd454eb90474d2d27c313f
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spelling	oai:doaj.org-article:1bbb3cacc2fd454eb90474d2d27c313f2021-12-02T16:51:30ZNext generation plasma proteome profiling to monitor health and disease10.1038/s41467-021-22767-z2041-1723https://doaj.org/article/1bbb3cacc2fd454eb90474d2d27c313f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22767-zhttps://doaj.org/toc/2041-1723The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.Wen ZhongFredrik EdforsAnders GummessonGöran BergströmLinn FagerbergMathias UhlénNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Zhong Fredrik Edfors Anders Gummesson Göran Bergström Linn Fagerberg Mathias Uhlén Next generation plasma proteome profiling to monitor health and disease
description	The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.
format	article
author	Wen Zhong Fredrik Edfors Anders Gummesson Göran Bergström Linn Fagerberg Mathias Uhlén
author_facet	Wen Zhong Fredrik Edfors Anders Gummesson Göran Bergström Linn Fagerberg Mathias Uhlén
author_sort	Wen Zhong
title	Next generation plasma proteome profiling to monitor health and disease
title_short	Next generation plasma proteome profiling to monitor health and disease
title_full	Next generation plasma proteome profiling to monitor health and disease
title_fullStr	Next generation plasma proteome profiling to monitor health and disease
title_full_unstemmed	Next generation plasma proteome profiling to monitor health and disease
title_sort	next generation plasma proteome profiling to monitor health and disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1bbb3cacc2fd454eb90474d2d27c313f
work_keys_str_mv	AT wenzhong nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT fredrikedfors nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT andersgummesson nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT goranbergstrom nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT linnfagerberg nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT mathiasuhlen nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease
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Next generation plasma proteome profiling to monitor health and disease

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