Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical mechanism for decoding selenocysteine.

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Autores principales:	Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bc117eaac2c4b32ae01b3db056620d1
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spelling	oai:doaj.org-article:1bc117eaac2c4b32ae01b3db056620d12021-12-02T16:57:02ZCrystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation10.1038/ncomms129412041-1723https://doaj.org/article/1bc117eaac2c4b32ae01b3db056620d12016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12941https://doaj.org/toc/2041-1723Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical mechanism for decoding selenocysteine.Malgorzata Dobosz-BartoszekMark H. PinkertonZbyszek OtwinowskiSrinivas ChakravarthyDieter SöllPaul R. CopelandMiljan SimonovićNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Malgorzata Dobosz-Bartoszek Mark H. Pinkerton Zbyszek Otwinowski Srinivas Chakravarthy Dieter Söll Paul R. Copeland Miljan Simonović Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
description	Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical mechanism for decoding selenocysteine.
format	article
author	Malgorzata Dobosz-Bartoszek Mark H. Pinkerton Zbyszek Otwinowski Srinivas Chakravarthy Dieter Söll Paul R. Copeland Miljan Simonović
author_facet	Malgorzata Dobosz-Bartoszek Mark H. Pinkerton Zbyszek Otwinowski Srinivas Chakravarthy Dieter Söll Paul R. Copeland Miljan Simonović
author_sort	Malgorzata Dobosz-Bartoszek
title	Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
title_short	Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
title_full	Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
title_fullStr	Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
title_full_unstemmed	Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation
title_sort	crystal structures of the human elongation factor eefsec suggest a non-canonical mechanism for selenocysteine incorporation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1bc117eaac2c4b32ae01b3db056620d1
work_keys_str_mv	AT malgorzatadoboszbartoszek crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation AT markhpinkerton crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation AT zbyszekotwinowski crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation AT srinivaschakravarthy crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation AT dietersoll crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation AT paulrcopeland crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation AT miljansimonovic crystalstructuresofthehumanelongationfactoreefsecsuggestanoncanonicalmechanismforselenocysteineincorporation
_version_	1718382610086887424

Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

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