Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes

Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal...

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Autores principales:	Daoming Li, Yang Zhu, Yonghua Wang, Qiong Zou, Jinzhu Duan, Dongxiao Sun-Waterhouse, Baoguo Sun
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Diacylglycerols Functional oil Insulin sensitivity Lipidomics Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/1bc409a11f3043f581ae9659be7c581e
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spelling	oai:doaj.org-article:1bc409a11f3043f581ae9659be7c581e2021-11-28T04:31:47ZPerspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes2213-453010.1016/j.fshw.2021.11.004https://doaj.org/article/1bc409a11f3043f581ae9659be7c581e2022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213453021000987https://doaj.org/toc/2213-4530Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-DAGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic patients. This conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their metabolism. To make a contribution to this field, this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs (ingested and endogenous) in the change of insulin sensitivity. Accordingly, strategies for further investigations on the metabolism of DAGs are proposed.Daoming LiYang ZhuYonghua WangQiong ZouJinzhu DuanDongxiao Sun-WaterhouseBaoguo SunKeAi Communications Co., Ltd.articleDiacylglycerolsFunctional oilInsulin sensitivityLipidomicsNutrition. Foods and food supplyTX341-641ENFood Science and Human Wellness, Vol 11, Iss 2, Pp 230-237 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diacylglycerols Functional oil Insulin sensitivity Lipidomics Nutrition. Foods and food supply TX341-641
spellingShingle	Diacylglycerols Functional oil Insulin sensitivity Lipidomics Nutrition. Foods and food supply TX341-641 Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
description	Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-DAGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic patients. This conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their metabolism. To make a contribution to this field, this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs (ingested and endogenous) in the change of insulin sensitivity. Accordingly, strategies for further investigations on the metabolism of DAGs are proposed.
format	article
author	Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun
author_facet	Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun
author_sort	Daoming Li
title	Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
title_short	Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
title_full	Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
title_fullStr	Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
title_full_unstemmed	Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
title_sort	perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/1bc409a11f3043f581ae9659be7c581e
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Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes

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