Identification of 22 susceptibility loci associated with testicular germ cell tumors

Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.

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Autores principales:	John Pluta, Louise C. Pyle, Kevin T. Nead, Rona Wilf, Mingyao Li, Nandita Mitra, Benita Weathers, Kurt D’Andrea, Kristian Almstrup, Lynn Anson-Cartwright, Javier Benitez, Christopher D. Brown, Stephen Chanock, Chu Chen, Victoria K. Cortessis, Alberto Ferlin, Carlo Foresta, Marija Gamulin, Jourik A. Gietema, Chiara Grasso, Mark H. Greene, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Russ Hauser, Michelle A. T. Hildebrandt, Matthew E. Johnson, Robert Karlsson, Lambertus A. Kiemeney, Davor Lessel, Ragnhild A. Lothe, Jennifer T. Loud, Chey Loveday, Paloma Martin-Gimeno, Coby Meijer, Jérémie Nsengimana, David I. Quinn, Thorunn Rafnar, Shweta Ramdas, Lorenzo Richiardi, Rolf I. Skotheim, Kari Stefansson, Clare Turnbull, David J. Vaughn, Fredrik Wiklund, Xifeng Wu, Daphne Yang, Tongzhang Zheng, Andrew D. Wells, Struan F. A. Grant, Ewa Rajpert-De Meyts, Stephen M. Schwartz, D. Timothy Bishop, Katherine A. McGlynn, Peter A. Kanetsky, Katherine L. Nathanson, The Testicular Cancer Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bc43b27ac0f4b2690a3ddaf9399e619
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spelling	oai:doaj.org-article:1bc43b27ac0f4b2690a3ddaf9399e6192021-12-02T16:26:40ZIdentification of 22 susceptibility loci associated with testicular germ cell tumors10.1038/s41467-021-24334-y2041-1723https://doaj.org/article/1bc43b27ac0f4b2690a3ddaf9399e6192021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24334-yhttps://doaj.org/toc/2041-1723Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.John PlutaLouise C. PyleKevin T. NeadRona WilfMingyao LiNandita MitraBenita WeathersKurt D’AndreaKristian AlmstrupLynn Anson-CartwrightJavier BenitezChristopher D. BrownStephen ChanockChu ChenVictoria K. CortessisAlberto FerlinCarlo ForestaMarija GamulinJourik A. GietemaChiara GrassoMark H. GreeneTom GrotmolRobert J. HamiltonTrine B. HaugenRuss HauserMichelle A. T. HildebrandtMatthew E. JohnsonRobert KarlssonLambertus A. KiemeneyDavor LesselRagnhild A. LotheJennifer T. LoudChey LovedayPaloma Martin-GimenoCoby MeijerJérémie NsengimanaDavid I. QuinnThorunn RafnarShweta RamdasLorenzo RichiardiRolf I. SkotheimKari StefanssonClare TurnbullDavid J. VaughnFredrik WiklundXifeng WuDaphne YangTongzhang ZhengAndrew D. WellsStruan F. A. GrantEwa Rajpert-De MeytsStephen M. SchwartzD. Timothy BishopKatherine A. McGlynnPeter A. KanetskyKatherine L. NathansonThe Testicular Cancer ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John Pluta Louise C. Pyle Kevin T. Nead Rona Wilf Mingyao Li Nandita Mitra Benita Weathers Kurt D’Andrea Kristian Almstrup Lynn Anson-Cartwright Javier Benitez Christopher D. Brown Stephen Chanock Chu Chen Victoria K. Cortessis Alberto Ferlin Carlo Foresta Marija Gamulin Jourik A. Gietema Chiara Grasso Mark H. Greene Tom Grotmol Robert J. Hamilton Trine B. Haugen Russ Hauser Michelle A. T. Hildebrandt Matthew E. Johnson Robert Karlsson Lambertus A. Kiemeney Davor Lessel Ragnhild A. Lothe Jennifer T. Loud Chey Loveday Paloma Martin-Gimeno Coby Meijer Jérémie Nsengimana David I. Quinn Thorunn Rafnar Shweta Ramdas Lorenzo Richiardi Rolf I. Skotheim Kari Stefansson Clare Turnbull David J. Vaughn Fredrik Wiklund Xifeng Wu Daphne Yang Tongzhang Zheng Andrew D. Wells Struan F. A. Grant Ewa Rajpert-De Meyts Stephen M. Schwartz D. Timothy Bishop Katherine A. McGlynn Peter A. Kanetsky Katherine L. Nathanson The Testicular Cancer Consortium Identification of 22 susceptibility loci associated with testicular germ cell tumors
description	Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.
format	article
author	John Pluta Louise C. Pyle Kevin T. Nead Rona Wilf Mingyao Li Nandita Mitra Benita Weathers Kurt D’Andrea Kristian Almstrup Lynn Anson-Cartwright Javier Benitez Christopher D. Brown Stephen Chanock Chu Chen Victoria K. Cortessis Alberto Ferlin Carlo Foresta Marija Gamulin Jourik A. Gietema Chiara Grasso Mark H. Greene Tom Grotmol Robert J. Hamilton Trine B. Haugen Russ Hauser Michelle A. T. Hildebrandt Matthew E. Johnson Robert Karlsson Lambertus A. Kiemeney Davor Lessel Ragnhild A. Lothe Jennifer T. Loud Chey Loveday Paloma Martin-Gimeno Coby Meijer Jérémie Nsengimana David I. Quinn Thorunn Rafnar Shweta Ramdas Lorenzo Richiardi Rolf I. Skotheim Kari Stefansson Clare Turnbull David J. Vaughn Fredrik Wiklund Xifeng Wu Daphne Yang Tongzhang Zheng Andrew D. Wells Struan F. A. Grant Ewa Rajpert-De Meyts Stephen M. Schwartz D. Timothy Bishop Katherine A. McGlynn Peter A. Kanetsky Katherine L. Nathanson The Testicular Cancer Consortium
author_facet	John Pluta Louise C. Pyle Kevin T. Nead Rona Wilf Mingyao Li Nandita Mitra Benita Weathers Kurt D’Andrea Kristian Almstrup Lynn Anson-Cartwright Javier Benitez Christopher D. Brown Stephen Chanock Chu Chen Victoria K. Cortessis Alberto Ferlin Carlo Foresta Marija Gamulin Jourik A. Gietema Chiara Grasso Mark H. Greene Tom Grotmol Robert J. Hamilton Trine B. Haugen Russ Hauser Michelle A. T. Hildebrandt Matthew E. Johnson Robert Karlsson Lambertus A. Kiemeney Davor Lessel Ragnhild A. Lothe Jennifer T. Loud Chey Loveday Paloma Martin-Gimeno Coby Meijer Jérémie Nsengimana David I. Quinn Thorunn Rafnar Shweta Ramdas Lorenzo Richiardi Rolf I. Skotheim Kari Stefansson Clare Turnbull David J. Vaughn Fredrik Wiklund Xifeng Wu Daphne Yang Tongzhang Zheng Andrew D. Wells Struan F. A. Grant Ewa Rajpert-De Meyts Stephen M. Schwartz D. Timothy Bishop Katherine A. McGlynn Peter A. Kanetsky Katherine L. Nathanson The Testicular Cancer Consortium
author_sort	John Pluta
title	Identification of 22 susceptibility loci associated with testicular germ cell tumors
title_short	Identification of 22 susceptibility loci associated with testicular germ cell tumors
title_full	Identification of 22 susceptibility loci associated with testicular germ cell tumors
title_fullStr	Identification of 22 susceptibility loci associated with testicular germ cell tumors
title_full_unstemmed	Identification of 22 susceptibility loci associated with testicular germ cell tumors
title_sort	identification of 22 susceptibility loci associated with testicular germ cell tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1bc43b27ac0f4b2690a3ddaf9399e619
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Identification of 22 susceptibility loci associated with testicular germ cell tumors

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