Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution

Ionizing radiation and chemotherapy deplete haematopoietic stem cells and damage the vascular niche. Here the authors show that irradiation induces SEMA3A secretion from bone marrow endothelial cells (ECs), inducing EC apoptosis via NRP1 and that NRP1 inhibition promotes vascular regeneration and R...

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Autores principales:	Christina M. Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y. Chang, Yurun Zhang, Nicollette J. Setiawan, Lia Signaevskaia, Michelle Li, Mindy M. Kim, Orel Tabibi, Paulina K. Lin, Joshua P. Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A. Himburg, John P. Chute
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bc7079a69604192ab5c5cd6cd2c1289
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spelling	oai:doaj.org-article:1bc7079a69604192ab5c5cd6cd2c12892021-12-05T12:22:56ZNeuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution10.1038/s41467-021-27263-y2041-1723https://doaj.org/article/1bc7079a69604192ab5c5cd6cd2c12892021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27263-yhttps://doaj.org/toc/2041-1723Ionizing radiation and chemotherapy deplete haematopoietic stem cells and damage the vascular niche. Here the authors show that irradiation induces SEMA3A secretion from bone marrow endothelial cells (ECs), inducing EC apoptosis via NRP1 and that NRP1 inhibition promotes vascular regeneration and R spondin 2 dependent hematopoietic regeneration.Christina M. TerminiAmara PangTiancheng FangMartina RoosVivian Y. ChangYurun ZhangNicollette J. SetiawanLia SignaevskaiaMichelle LiMindy M. KimOrel TabibiPaulina K. LinJoshua P. SasineAvradip ChatterjeeRamachandran MuraliHeather A. HimburgJohn P. ChuteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina M. Termini Amara Pang Tiancheng Fang Martina Roos Vivian Y. Chang Yurun Zhang Nicollette J. Setiawan Lia Signaevskaia Michelle Li Mindy M. Kim Orel Tabibi Paulina K. Lin Joshua P. Sasine Avradip Chatterjee Ramachandran Murali Heather A. Himburg John P. Chute Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
description	Ionizing radiation and chemotherapy deplete haematopoietic stem cells and damage the vascular niche. Here the authors show that irradiation induces SEMA3A secretion from bone marrow endothelial cells (ECs), inducing EC apoptosis via NRP1 and that NRP1 inhibition promotes vascular regeneration and R spondin 2 dependent hematopoietic regeneration.
format	article
author	Christina M. Termini Amara Pang Tiancheng Fang Martina Roos Vivian Y. Chang Yurun Zhang Nicollette J. Setiawan Lia Signaevskaia Michelle Li Mindy M. Kim Orel Tabibi Paulina K. Lin Joshua P. Sasine Avradip Chatterjee Ramachandran Murali Heather A. Himburg John P. Chute
author_facet	Christina M. Termini Amara Pang Tiancheng Fang Martina Roos Vivian Y. Chang Yurun Zhang Nicollette J. Setiawan Lia Signaevskaia Michelle Li Mindy M. Kim Orel Tabibi Paulina K. Lin Joshua P. Sasine Avradip Chatterjee Ramachandran Murali Heather A. Himburg John P. Chute
author_sort	Christina M. Termini
title	Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
title_short	Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
title_full	Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
title_fullStr	Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
title_full_unstemmed	Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
title_sort	neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1bc7079a69604192ab5c5cd6cd2c1289
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_version_	1718372002910175232

Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution

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