Role of adrenergic receptor signalling in neuroimmune communication

Neuroimmune communication plays a crucial role in maintaining homeostasis and promptly responding to any foreign insults. Sympathetic nerve fibres are innervated into all the lymphoid organs (bone marrow, thymus, spleen, and lymph nodes) and provide a communication link between the central nervous s...

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Autores principales:	Sushanta Chhatar, Girdhari Lal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Adrenaline Adrenergic receptors Epinephrine Nerve-driven immunity Neuroimmune communication Neurotransmitters Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1bcaa21f51114ddd88f9df6298df40a1
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spelling	oai:doaj.org-article:1bcaa21f51114ddd88f9df6298df40a12021-11-26T04:39:56ZRole of adrenergic receptor signalling in neuroimmune communication2590-255510.1016/j.crimmu.2021.11.001https://doaj.org/article/1bcaa21f51114ddd88f9df6298df40a12021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590255521000238https://doaj.org/toc/2590-2555Neuroimmune communication plays a crucial role in maintaining homeostasis and promptly responding to any foreign insults. Sympathetic nerve fibres are innervated into all the lymphoid organs (bone marrow, thymus, spleen, and lymph nodes) and provide a communication link between the central nervous system (CNS) and ongoing immune response in the tissue microenvironment. Neurotransmitters such as catecholamines (epinephrine and norepinephrine) bind to adrenergic receptors present on most immune and non-immune cells, establish a local neuroimmune-communication system, and help regulate the ongoing immune response. The activation of these receptors varies with the type of receptor-activated, target cell, the activation status of the cells, and timing of activation. Activating adrenergic receptors, specifically β-adrenergic signalling in immune cells leads to activation of the cAMP-PKA pathway or other non-canonical pathways. It predominantly leads to immune suppression such as inhibition of IL-2 secretion and a decrease in macrophages phagocytosis. This review discusses the expression of different adrenergic receptors in various immune cells, signalling, and how it modulates immune cell function and contributes to health and diseases. Understanding the neuroimmune communication through adrenergic receptor signalling in immune cells could help to design better strategies to control inflammation and autoimmunity.Sushanta ChhatarGirdhari LalElsevierarticleAdrenalineAdrenergic receptorsEpinephrineNerve-driven immunityNeuroimmune communicationNeurotransmittersSpecialties of internal medicineRC581-951ENCurrent Research in Immunology, Vol 2, Iss , Pp 202-217 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adrenaline Adrenergic receptors Epinephrine Nerve-driven immunity Neuroimmune communication Neurotransmitters Specialties of internal medicine RC581-951
spellingShingle	Adrenaline Adrenergic receptors Epinephrine Nerve-driven immunity Neuroimmune communication Neurotransmitters Specialties of internal medicine RC581-951 Sushanta Chhatar Girdhari Lal Role of adrenergic receptor signalling in neuroimmune communication
description	Neuroimmune communication plays a crucial role in maintaining homeostasis and promptly responding to any foreign insults. Sympathetic nerve fibres are innervated into all the lymphoid organs (bone marrow, thymus, spleen, and lymph nodes) and provide a communication link between the central nervous system (CNS) and ongoing immune response in the tissue microenvironment. Neurotransmitters such as catecholamines (epinephrine and norepinephrine) bind to adrenergic receptors present on most immune and non-immune cells, establish a local neuroimmune-communication system, and help regulate the ongoing immune response. The activation of these receptors varies with the type of receptor-activated, target cell, the activation status of the cells, and timing of activation. Activating adrenergic receptors, specifically β-adrenergic signalling in immune cells leads to activation of the cAMP-PKA pathway or other non-canonical pathways. It predominantly leads to immune suppression such as inhibition of IL-2 secretion and a decrease in macrophages phagocytosis. This review discusses the expression of different adrenergic receptors in various immune cells, signalling, and how it modulates immune cell function and contributes to health and diseases. Understanding the neuroimmune communication through adrenergic receptor signalling in immune cells could help to design better strategies to control inflammation and autoimmunity.
format	article
author	Sushanta Chhatar Girdhari Lal
author_facet	Sushanta Chhatar Girdhari Lal
author_sort	Sushanta Chhatar
title	Role of adrenergic receptor signalling in neuroimmune communication
title_short	Role of adrenergic receptor signalling in neuroimmune communication
title_full	Role of adrenergic receptor signalling in neuroimmune communication
title_fullStr	Role of adrenergic receptor signalling in neuroimmune communication
title_full_unstemmed	Role of adrenergic receptor signalling in neuroimmune communication
title_sort	role of adrenergic receptor signalling in neuroimmune communication
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1bcaa21f51114ddd88f9df6298df40a1
work_keys_str_mv	AT sushantachhatar roleofadrenergicreceptorsignallinginneuroimmunecommunication AT girdharilal roleofadrenergicreceptorsignallinginneuroimmunecommunication
_version_	1718409825796227072

Role of adrenergic receptor signalling in neuroimmune communication

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