Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents

Inflammaging, the steady development of the inflammatory state over age is an attributable characteristic of aging that potentiates the initiation of pathogenesis in many age-related disorders (ARDs) including neurodegenerative diseases, arthritis, cancer, atherosclerosis, type 2 diabetes, and osteo...

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Autores principales:	Sushruta Koppula, Mahbuba Akther, Md Ezazul Haque, Spandana Rajendra Kopalli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammaging aging related disorders low grade inflammation nutrients natural herbs pro-inflammatory cytokines Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/1bcb3d5478844a2a9ddc4db8cb0224a8
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spelling	oai:doaj.org-article:1bcb3d5478844a2a9ddc4db8cb0224a82021-11-25T18:36:27ZPotential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents10.3390/nu131140582072-6643https://doaj.org/article/1bcb3d5478844a2a9ddc4db8cb0224a82021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4058https://doaj.org/toc/2072-6643Inflammaging, the steady development of the inflammatory state over age is an attributable characteristic of aging that potentiates the initiation of pathogenesis in many age-related disorders (ARDs) including neurodegenerative diseases, arthritis, cancer, atherosclerosis, type 2 diabetes, and osteoporosis. Inflammaging is characterized by subclinical chronic, low grade, steady inflammatory states and is considered a crucial underlying cause behind the high mortality and morbidity rate associated with ARDs. Although a coherent set of studies detailed the underlying pathomechanisms of inflammaging, the potential benefits from non-toxic nutrients from natural and synthetic sources in modulating or delaying inflammaging processes was not discussed. In this review, the available literature and recent updates of natural and synthetic nutrients that help in controlling inflammaging process was explored. Also, we discussed the clinical trial reports and patent claims on potential nutrients demonstrating therapeutic benefits in controlling inflammaging and inflammation-associated ARDs.Sushruta KoppulaMahbuba AktherMd Ezazul HaqueSpandana Rajendra KopalliMDPI AGarticleinflammagingaging related disorderslow grade inflammationnutrientsnatural herbspro-inflammatory cytokinesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4058, p 4058 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammaging aging related disorders low grade inflammation nutrients natural herbs pro-inflammatory cytokines Nutrition. Foods and food supply TX341-641
spellingShingle	inflammaging aging related disorders low grade inflammation nutrients natural herbs pro-inflammatory cytokines Nutrition. Foods and food supply TX341-641 Sushruta Koppula Mahbuba Akther Md Ezazul Haque Spandana Rajendra Kopalli Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
description	Inflammaging, the steady development of the inflammatory state over age is an attributable characteristic of aging that potentiates the initiation of pathogenesis in many age-related disorders (ARDs) including neurodegenerative diseases, arthritis, cancer, atherosclerosis, type 2 diabetes, and osteoporosis. Inflammaging is characterized by subclinical chronic, low grade, steady inflammatory states and is considered a crucial underlying cause behind the high mortality and morbidity rate associated with ARDs. Although a coherent set of studies detailed the underlying pathomechanisms of inflammaging, the potential benefits from non-toxic nutrients from natural and synthetic sources in modulating or delaying inflammaging processes was not discussed. In this review, the available literature and recent updates of natural and synthetic nutrients that help in controlling inflammaging process was explored. Also, we discussed the clinical trial reports and patent claims on potential nutrients demonstrating therapeutic benefits in controlling inflammaging and inflammation-associated ARDs.
format	article
author	Sushruta Koppula Mahbuba Akther Md Ezazul Haque Spandana Rajendra Kopalli
author_facet	Sushruta Koppula Mahbuba Akther Md Ezazul Haque Spandana Rajendra Kopalli
author_sort	Sushruta Koppula
title	Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
title_short	Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
title_full	Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
title_fullStr	Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
title_full_unstemmed	Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
title_sort	potential nutrients from natural and synthetic sources targeting inflammaging—a review of literature, clinical data and patents
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1bcb3d5478844a2a9ddc4db8cb0224a8
work_keys_str_mv	AT sushrutakoppula potentialnutrientsfromnaturalandsyntheticsourcestargetinginflammagingareviewofliteratureclinicaldataandpatents AT mahbubaakther potentialnutrientsfromnaturalandsyntheticsourcestargetinginflammagingareviewofliteratureclinicaldataandpatents AT mdezazulhaque potentialnutrientsfromnaturalandsyntheticsourcestargetinginflammagingareviewofliteratureclinicaldataandpatents AT spandanarajendrakopalli potentialnutrientsfromnaturalandsyntheticsourcestargetinginflammagingareviewofliteratureclinicaldataandpatents
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Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents

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