Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a We...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lindsey S. Treviño, Jianrong Dong, Ahkilesh Kaushal, Tiffany A. Katz, Rahul Kumar Jangid, Matthew J. Robertson, Sandra L. Grimm, Chandra Shekar R. Ambati, Vasanta Putluri, Aaron R. Cox, Kang Ho Kim, Thaddeus D. May, Morgan R. Gallo, David D. Moore, Sean M. Hartig, Charles E. Foulds, Nagireddy Putluri, Cristian Coarfa, Cheryl Lyn Walker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bd07351812944de819b5ad960475b3b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1bd07351812944de819b5ad960475b3b
record_format	dspace
spelling	oai:doaj.org-article:1bd07351812944de819b5ad960475b3b2021-12-02T15:37:11ZEpigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood10.1038/s41467-020-15847-z2041-1723https://doaj.org/article/1bd07351812944de819b5ad960475b3b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15847-zhttps://doaj.org/toc/2041-1723Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet.Lindsey S. TreviñoJianrong DongAhkilesh KaushalTiffany A. KatzRahul Kumar JangidMatthew J. RobertsonSandra L. GrimmChandra Shekar R. AmbatiVasanta PutluriAaron R. CoxKang Ho KimThaddeus D. MayMorgan R. GalloDavid D. MooreSean M. HartigCharles E. FouldsNagireddy PutluriCristian CoarfaCheryl Lyn WalkerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lindsey S. Treviño Jianrong Dong Ahkilesh Kaushal Tiffany A. Katz Rahul Kumar Jangid Matthew J. Robertson Sandra L. Grimm Chandra Shekar R. Ambati Vasanta Putluri Aaron R. Cox Kang Ho Kim Thaddeus D. May Morgan R. Gallo David D. Moore Sean M. Hartig Charles E. Foulds Nagireddy Putluri Cristian Coarfa Cheryl Lyn Walker Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
description	Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet.
format	article
author	Lindsey S. Treviño Jianrong Dong Ahkilesh Kaushal Tiffany A. Katz Rahul Kumar Jangid Matthew J. Robertson Sandra L. Grimm Chandra Shekar R. Ambati Vasanta Putluri Aaron R. Cox Kang Ho Kim Thaddeus D. May Morgan R. Gallo David D. Moore Sean M. Hartig Charles E. Foulds Nagireddy Putluri Cristian Coarfa Cheryl Lyn Walker
author_facet	Lindsey S. Treviño Jianrong Dong Ahkilesh Kaushal Tiffany A. Katz Rahul Kumar Jangid Matthew J. Robertson Sandra L. Grimm Chandra Shekar R. Ambati Vasanta Putluri Aaron R. Cox Kang Ho Kim Thaddeus D. May Morgan R. Gallo David D. Moore Sean M. Hartig Charles E. Foulds Nagireddy Putluri Cristian Coarfa Cheryl Lyn Walker
author_sort	Lindsey S. Treviño
title	Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
title_short	Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
title_full	Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
title_fullStr	Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
title_full_unstemmed	Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
title_sort	epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1bd07351812944de819b5ad960475b3b
work_keys_str_mv	AT lindseystrevino epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT jianrongdong epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT ahkileshkaushal epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT tiffanyakatz epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT rahulkumarjangid epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT matthewjrobertson epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT sandralgrimm epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT chandrashekarrambati epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT vasantaputluri epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT aaronrcox epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT kanghokim epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT thaddeusdmay epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT morganrgallo epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT daviddmoore epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT seanmhartig epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT charlesefoulds epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT nagireddyputluri epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT cristiancoarfa epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood AT cheryllynwalker epigenomeenvironmentinteractionsaccelerateepigenomicagingandunlockmetabolicallyrestrictedepigeneticreprogramminginadulthood
_version_	1718386218172940288

Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Ejemplares similares