PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus

Phc1 is a subunit of the polycomb repressive complex 1 (PRC1), which represses gene expression during development. Here the authors show that Phc1 acts independently from PRC1 to activate Nanog transcription by stabilizing genome-wide chromatin interactions of the Nanog locus, and in turn stabilize...

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Autores principales:	Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen, Junfeng Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bd744e8053240e3be81e1d9849f044b
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spelling	oai:doaj.org-article:1bd744e8053240e3be81e1d9849f044b2021-12-02T15:54:54ZPHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus10.1038/s41467-021-22871-02041-1723https://doaj.org/article/1bd744e8053240e3be81e1d9849f044b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22871-0https://doaj.org/toc/2041-1723Phc1 is a subunit of the polycomb repressive complex 1 (PRC1), which represses gene expression during development. Here the authors show that Phc1 acts independently from PRC1 to activate Nanog transcription by stabilizing genome-wide chromatin interactions of the Nanog locus, and in turn stabilize pluripotency.Li ChenQiaoqiao TongXiaowen ChenPenglei JiangHua YuQianbing ZhaoLingang SunChao LiuBin GuYuping ZhengLijiang FeiXiao JiangWenjuan LiGiacomo VolpeMazid MD. AbdulGuoji GuoJin ZhangPengxu QianQiming SunDante NeculaiMiguel A. EstebanChen LiFeiqiu WenJunfeng JiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Chen Qiaoqiao Tong Xiaowen Chen Penglei Jiang Hua Yu Qianbing Zhao Lingang Sun Chao Liu Bin Gu Yuping Zheng Lijiang Fei Xiao Jiang Wenjuan Li Giacomo Volpe Mazid MD. Abdul Guoji Guo Jin Zhang Pengxu Qian Qiming Sun Dante Neculai Miguel A. Esteban Chen Li Feiqiu Wen Junfeng Ji PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
description	Phc1 is a subunit of the polycomb repressive complex 1 (PRC1), which represses gene expression during development. Here the authors show that Phc1 acts independently from PRC1 to activate Nanog transcription by stabilizing genome-wide chromatin interactions of the Nanog locus, and in turn stabilize pluripotency.
format	article
author	Li Chen Qiaoqiao Tong Xiaowen Chen Penglei Jiang Hua Yu Qianbing Zhao Lingang Sun Chao Liu Bin Gu Yuping Zheng Lijiang Fei Xiao Jiang Wenjuan Li Giacomo Volpe Mazid MD. Abdul Guoji Guo Jin Zhang Pengxu Qian Qiming Sun Dante Neculai Miguel A. Esteban Chen Li Feiqiu Wen Junfeng Ji
author_facet	Li Chen Qiaoqiao Tong Xiaowen Chen Penglei Jiang Hua Yu Qianbing Zhao Lingang Sun Chao Liu Bin Gu Yuping Zheng Lijiang Fei Xiao Jiang Wenjuan Li Giacomo Volpe Mazid MD. Abdul Guoji Guo Jin Zhang Pengxu Qian Qiming Sun Dante Neculai Miguel A. Esteban Chen Li Feiqiu Wen Junfeng Ji
author_sort	Li Chen
title	PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
title_short	PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
title_full	PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
title_fullStr	PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
title_full_unstemmed	PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
title_sort	phc1 maintains pluripotency by organizing genome-wide chromatin interactions of the nanog locus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1bd744e8053240e3be81e1d9849f044b
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PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus

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