Chromosome drives via CRISPR-Cas9 in yeast

Chromosome drives via CRISPR-Cas9 in yeast

Self-propagating drives allow for non-Mendelian inheritance. Here the authors use CRISPR to build a chromosome drive, showing elimination of entire chromosomes, endoreduplication of desired chromosomes and enabling preferential transmissions of complex genetic traits on a chromosomal scale in yeast.

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Autores principales: Hui Xu, Mingzhe Han, Shiyi Zhou, Bing-Zhi Li, Yi Wu, Ying-Jin Yuan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/1bd81577b51e4b508048788982ed323d
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spelling oai:doaj.org-article:1bd81577b51e4b508048788982ed323d2021-12-02T18:53:11ZChromosome drives via CRISPR-Cas9 in yeast10.1038/s41467-020-18222-02041-1723https://doaj.org/article/1bd81577b51e4b508048788982ed323d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18222-0https://doaj.org/toc/2041-1723Self-propagating drives allow for non-Mendelian inheritance. Here the authors use CRISPR to build a chromosome drive, showing elimination of entire chromosomes, endoreduplication of desired chromosomes and enabling preferential transmissions of complex genetic traits on a chromosomal scale in yeast.Hui XuMingzhe HanShiyi ZhouBing-Zhi LiYi WuYing-Jin YuanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hui Xu
Mingzhe Han
Shiyi Zhou
Bing-Zhi Li
Yi Wu
Ying-Jin Yuan
Chromosome drives via CRISPR-Cas9 in yeast
description Self-propagating drives allow for non-Mendelian inheritance. Here the authors use CRISPR to build a chromosome drive, showing elimination of entire chromosomes, endoreduplication of desired chromosomes and enabling preferential transmissions of complex genetic traits on a chromosomal scale in yeast.
format article
author Hui Xu
Mingzhe Han
Shiyi Zhou
Bing-Zhi Li
Yi Wu
Ying-Jin Yuan
author_facet Hui Xu
Mingzhe Han
Shiyi Zhou
Bing-Zhi Li
Yi Wu
Ying-Jin Yuan
author_sort Hui Xu
title Chromosome drives via CRISPR-Cas9 in yeast
title_short Chromosome drives via CRISPR-Cas9 in yeast
title_full Chromosome drives via CRISPR-Cas9 in yeast
title_fullStr Chromosome drives via CRISPR-Cas9 in yeast
title_full_unstemmed Chromosome drives via CRISPR-Cas9 in yeast
title_sort chromosome drives via crispr-cas9 in yeast
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1bd81577b51e4b508048788982ed323d
work_keys_str_mv AT huixu chromosomedrivesviacrisprcas9inyeast
AT mingzhehan chromosomedrivesviacrisprcas9inyeast
AT shiyizhou chromosomedrivesviacrisprcas9inyeast
AT bingzhili chromosomedrivesviacrisprcas9inyeast
AT yiwu chromosomedrivesviacrisprcas9inyeast
AT yingjinyuan chromosomedrivesviacrisprcas9inyeast
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