The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study

Abstract Nontyphoidal salmonella (NTS) infection has a high mortality rate. Bowel resections affect gut microbiota and immune function, and the association between bowel resection and NTS infection in human beings has not been addressed. We conducted a nationwide propensity score (PS)-matched cohort...

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Autores principales:	Kuang-Tsu Yang, Sin-Ei Juang, Yao-Min Hung, James Cheng-Chung Wei, Hei-Tung Yip, Renin Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1bdc2d033c964ee3974452890592551c
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spelling	oai:doaj.org-article:1bdc2d033c964ee3974452890592551c2021-12-02T15:22:57ZThe association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study10.1038/s41598-021-81224-52045-2322https://doaj.org/article/1bdc2d033c964ee3974452890592551c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81224-5https://doaj.org/toc/2045-2322Abstract Nontyphoidal salmonella (NTS) infection has a high mortality rate. Bowel resections affect gut microbiota and immune function, and the association between bowel resection and NTS infection in human beings has not been addressed. We conducted a nationwide propensity score (PS)-matched cohort study to clarify this association. Data from the Longitudinal Health Insurance Database of Taiwan were used to establish a case-cohort with bowel resections from 2000 to 2013. Informed consent was waived by the Institutional Review Board of China Medical University Hospital (CMUH104-REC2-115) because all personal identifying information used had been de-identified. Each case was matched with one control without any bowel resection according to age, gender, index date, and propensity score (PS). Cumulative incidences of and hazard ratios (HRs) for NTS infection development were analyzed. The incidence of NTS infection was greater in patients with a bowel resection than in the control group (2.97 vs. 1.92 per 10,000 person-years), with an adjusted hazard ratio (aHR) of 1.64 (95% CI = 1.08–2.48). The incidence of NTS infection increased significantly for cases with small bowel resections and right hemicolectomies. Age (31–40 and > 50 years), hypertension, chronic kidney disease, chronic obstructive pulmonary disease, and autoimmune diseases were significant risk factors of NTS infection. Stratification analysis revealed that patients without comorbidities were prone to NTS infection after bowel resections. The increased risk of developing NTS infection could be related to the bowel resection. Specific age groups and comorbidities also contribute to increased risk of NTS infection.Kuang-Tsu YangSin-Ei JuangYao-Min HungJames Cheng-Chung WeiHei-Tung YipRenin ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuang-Tsu Yang Sin-Ei Juang Yao-Min Hung James Cheng-Chung Wei Hei-Tung Yip Renin Chang The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
description	Abstract Nontyphoidal salmonella (NTS) infection has a high mortality rate. Bowel resections affect gut microbiota and immune function, and the association between bowel resection and NTS infection in human beings has not been addressed. We conducted a nationwide propensity score (PS)-matched cohort study to clarify this association. Data from the Longitudinal Health Insurance Database of Taiwan were used to establish a case-cohort with bowel resections from 2000 to 2013. Informed consent was waived by the Institutional Review Board of China Medical University Hospital (CMUH104-REC2-115) because all personal identifying information used had been de-identified. Each case was matched with one control without any bowel resection according to age, gender, index date, and propensity score (PS). Cumulative incidences of and hazard ratios (HRs) for NTS infection development were analyzed. The incidence of NTS infection was greater in patients with a bowel resection than in the control group (2.97 vs. 1.92 per 10,000 person-years), with an adjusted hazard ratio (aHR) of 1.64 (95% CI = 1.08–2.48). The incidence of NTS infection increased significantly for cases with small bowel resections and right hemicolectomies. Age (31–40 and > 50 years), hypertension, chronic kidney disease, chronic obstructive pulmonary disease, and autoimmune diseases were significant risk factors of NTS infection. Stratification analysis revealed that patients without comorbidities were prone to NTS infection after bowel resections. The increased risk of developing NTS infection could be related to the bowel resection. Specific age groups and comorbidities also contribute to increased risk of NTS infection.
format	article
author	Kuang-Tsu Yang Sin-Ei Juang Yao-Min Hung James Cheng-Chung Wei Hei-Tung Yip Renin Chang
author_facet	Kuang-Tsu Yang Sin-Ei Juang Yao-Min Hung James Cheng-Chung Wei Hei-Tung Yip Renin Chang
author_sort	Kuang-Tsu Yang
title	The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
title_short	The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
title_full	The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
title_fullStr	The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
title_full_unstemmed	The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
title_sort	association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1bdc2d033c964ee3974452890592551c
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The association between bowel resection and the risk of nontyphoidal salmonella infection: a nationwide propensity score-matched cohort study

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