Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes

The aim was to assess the effect of silver nanoparticles on the expression of proand anti-apoptotic proteins caspase-3 and bcl-2 by discriminant analysis.Materials and methods. 120 sexually mature outbred male rats were divided into 8 groups (pure arabinogalactan (AG), pure poly-1-vinyl-1,2,4-triazo...

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Autores principales:	M. A. Novikov, E. A. Titov, V. A. Vokina, L. M. Sosedova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	nanocomposites silver nanoparticles apoptosis brain discriminant analyses Science Q
Acceso en línea:	https://doaj.org/article/1bddd015bbb64714870e5f620ef424f5
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spelling	oai:doaj.org-article:1bddd015bbb64714870e5f620ef424f52021-11-23T06:14:41ZMathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes2541-94202587-959610.29413/ABS.2018-3.6.22https://doaj.org/article/1bddd015bbb64714870e5f620ef424f52019-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1893https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim was to assess the effect of silver nanoparticles on the expression of proand anti-apoptotic proteins caspase-3 and bcl-2 by discriminant analysis.Materials and methods. 120 sexually mature outbred male rats were divided into 8 groups (pure arabinogalactan (AG), pure poly-1-vinyl-1,2,4-triazol (PVT), nanobiocomposites on the AG and PVT matrix at a dose of 100 and 500 μg/kg. The administration was done orally for 9 days. The experimental study was carried out in two stages. The first stage included the examination of animals immediately after the end of the exposure of the studied substances (early period), the second stage – a survey 6 months after the end of the exposure (the long-term period).Results. The most distinguished groups were the groups that were administered silver nanoparticles on the AG matrix at a dose of 100 and 500 μg/kg.Conclusion. Comparison of the results of the discriminant analysis allowed to fully determine the effect of silver nanoparticles on the expression of proand anti-apoptotic proteins caspase-3 and bcl-2 when they were introduced on the AG and PVT matrix. In the AG groups and nanobiocomposites based on it, in the feature space, it was shown that the most remote by differentiating characteristics are the groups nAG100 and nAG500. In nanocomposites on the PVT matrix, a group of animals differing in differentiating features has not been identified.M. A. NovikovE. A. TitovV. A. VokinaL. M. SosedovaScientific Сentre for Family Health and Human Reproduction Problemsarticlenanocompositessilvernanoparticlesapoptosisbraindiscriminant analysesScienceQRUActa Biomedica Scientifica, Vol 3, Iss 6, Pp 150-155 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	nanocomposites silver nanoparticles apoptosis brain discriminant analyses Science Q
spellingShingle	nanocomposites silver nanoparticles apoptosis brain discriminant analyses Science Q M. A. Novikov E. A. Titov V. A. Vokina L. M. Sosedova Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes
description	The aim was to assess the effect of silver nanoparticles on the expression of proand anti-apoptotic proteins caspase-3 and bcl-2 by discriminant analysis.Materials and methods. 120 sexually mature outbred male rats were divided into 8 groups (pure arabinogalactan (AG), pure poly-1-vinyl-1,2,4-triazol (PVT), nanobiocomposites on the AG and PVT matrix at a dose of 100 and 500 μg/kg. The administration was done orally for 9 days. The experimental study was carried out in two stages. The first stage included the examination of animals immediately after the end of the exposure of the studied substances (early period), the second stage – a survey 6 months after the end of the exposure (the long-term period).Results. The most distinguished groups were the groups that were administered silver nanoparticles on the AG matrix at a dose of 100 and 500 μg/kg.Conclusion. Comparison of the results of the discriminant analysis allowed to fully determine the effect of silver nanoparticles on the expression of proand anti-apoptotic proteins caspase-3 and bcl-2 when they were introduced on the AG and PVT matrix. In the AG groups and nanobiocomposites based on it, in the feature space, it was shown that the most remote by differentiating characteristics are the groups nAG100 and nAG500. In nanocomposites on the PVT matrix, a group of animals differing in differentiating features has not been identified.
format	article
author	M. A. Novikov E. A. Titov V. A. Vokina L. M. Sosedova
author_facet	M. A. Novikov E. A. Titov V. A. Vokina L. M. Sosedova
author_sort	M. A. Novikov
title	Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes
title_short	Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes
title_full	Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes
title_fullStr	Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes
title_full_unstemmed	Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes
title_sort	mathematical assessment of results of investigation of the bcl-2 and caspase-3 protein expression under the influence of nanobiocomposites of silver on natural and synthetic matrixes
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/1bddd015bbb64714870e5f620ef424f5
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Mathematical Assessment of Results of Investigation of the BCL-2 and Caspase-3 Protein Expression under the Influence of nanobiocomposites of Silver on natural and Synthetic Matrixes

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