ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

It is unclear how the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways interact with other signals in intestinal epithelial cells. Here, the authors show that upon loss of Erk1/2, or pharmacological inhibition of MEK1/2, the ERK5 pathway is upregulated to maintain epithelial cell pro...

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Autores principales:	Petrus R. de Jong, Koji Taniguchi, Alexandra R. Harris, Samuel Bertin, Naoki Takahashi, Jen Duong, Alejandro D. Campos, Garth Powis, Maripat Corr, Michael Karin, Eyal Raz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1be108f4d4194c2ab206271625dab19f
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spelling	oai:doaj.org-article:1be108f4d4194c2ab206271625dab19f2021-12-02T16:49:40ZERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation10.1038/ncomms115512041-1723https://doaj.org/article/1be108f4d4194c2ab206271625dab19f2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11551https://doaj.org/toc/2041-1723It is unclear how the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways interact with other signals in intestinal epithelial cells. Here, the authors show that upon loss of Erk1/2, or pharmacological inhibition of MEK1/2, the ERK5 pathway is upregulated to maintain epithelial cell proliferation.Petrus R. de JongKoji TaniguchiAlexandra R. HarrisSamuel BertinNaoki TakahashiJen DuongAlejandro D. CamposGarth PowisMaripat CorrMichael KarinEyal RazNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Petrus R. de Jong Koji Taniguchi Alexandra R. Harris Samuel Bertin Naoki Takahashi Jen Duong Alejandro D. Campos Garth Powis Maripat Corr Michael Karin Eyal Raz ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
description	It is unclear how the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways interact with other signals in intestinal epithelial cells. Here, the authors show that upon loss of Erk1/2, or pharmacological inhibition of MEK1/2, the ERK5 pathway is upregulated to maintain epithelial cell proliferation.
format	article
author	Petrus R. de Jong Koji Taniguchi Alexandra R. Harris Samuel Bertin Naoki Takahashi Jen Duong Alejandro D. Campos Garth Powis Maripat Corr Michael Karin Eyal Raz
author_facet	Petrus R. de Jong Koji Taniguchi Alexandra R. Harris Samuel Bertin Naoki Takahashi Jen Duong Alejandro D. Campos Garth Powis Maripat Corr Michael Karin Eyal Raz
author_sort	Petrus R. de Jong
title	ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
title_short	ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
title_full	ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
title_fullStr	ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
title_full_unstemmed	ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
title_sort	erk5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon erk1/2 abrogation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1be108f4d4194c2ab206271625dab19f
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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

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