NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

It is unclear whether arterial specification is required for hematopoietic stem cell formation. Here, the authors use a chemically defined human pluripotent stem cell (hPSC) differentiation system to show the role of NOTCH signaling in forming arterial-type hemogenic endothelial cells.

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Autores principales:	Gene I. Uenishi, Ho Sun Jung, Akhilesh Kumar, Mi Ae Park, Brandon K. Hadland, Ethan McLeod, Matthew Raymond, Oleg Moskvin, Catherine E. Zimmerman, Derek J. Theisen, Scott Swanson, Owen J. Tamplin, Leonard I. Zon, James A. Thomson, Irwin D. Bernstein, Igor I. Slukvin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1be185753919428b8cd64e6bff983c27
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spelling	oai:doaj.org-article:1be185753919428b8cd64e6bff983c272021-12-02T15:33:56ZNOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells10.1038/s41467-018-04134-72041-1723https://doaj.org/article/1be185753919428b8cd64e6bff983c272018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04134-7https://doaj.org/toc/2041-1723It is unclear whether arterial specification is required for hematopoietic stem cell formation. Here, the authors use a chemically defined human pluripotent stem cell (hPSC) differentiation system to show the role of NOTCH signaling in forming arterial-type hemogenic endothelial cells.Gene I. UenishiHo Sun JungAkhilesh KumarMi Ae ParkBrandon K. HadlandEthan McLeodMatthew RaymondOleg MoskvinCatherine E. ZimmermanDerek J. TheisenScott SwansonOwen J. TamplinLeonard I. ZonJames A. ThomsonIrwin D. BernsteinIgor I. SlukvinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gene I. Uenishi Ho Sun Jung Akhilesh Kumar Mi Ae Park Brandon K. Hadland Ethan McLeod Matthew Raymond Oleg Moskvin Catherine E. Zimmerman Derek J. Theisen Scott Swanson Owen J. Tamplin Leonard I. Zon James A. Thomson Irwin D. Bernstein Igor I. Slukvin NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
description	It is unclear whether arterial specification is required for hematopoietic stem cell formation. Here, the authors use a chemically defined human pluripotent stem cell (hPSC) differentiation system to show the role of NOTCH signaling in forming arterial-type hemogenic endothelial cells.
format	article
author	Gene I. Uenishi Ho Sun Jung Akhilesh Kumar Mi Ae Park Brandon K. Hadland Ethan McLeod Matthew Raymond Oleg Moskvin Catherine E. Zimmerman Derek J. Theisen Scott Swanson Owen J. Tamplin Leonard I. Zon James A. Thomson Irwin D. Bernstein Igor I. Slukvin
author_facet	Gene I. Uenishi Ho Sun Jung Akhilesh Kumar Mi Ae Park Brandon K. Hadland Ethan McLeod Matthew Raymond Oleg Moskvin Catherine E. Zimmerman Derek J. Theisen Scott Swanson Owen J. Tamplin Leonard I. Zon James A. Thomson Irwin D. Bernstein Igor I. Slukvin
author_sort	Gene I. Uenishi
title	NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
title_short	NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
title_full	NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
title_fullStr	NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
title_full_unstemmed	NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
title_sort	notch signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1be185753919428b8cd64e6bff983c27
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NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

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